PLDALPHA1 phospholipase D alpha 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PLDALPHA1
Official Full Name: phospholipase D alpha 1
Primary source: TAIR:AT3G15730
Locus tag: AT3G15730
See related: Araport:AT3G15730
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: PHOSPHOLIPASE D; phospholipase D alpha 1; PLD
Summary: Encodes phospholipase D alpha 1 (PLD alpha 1). Positive regulator of abscisic acid (ABA) mediated stomatal movements. PLD alpha 1 plays an important role in seed deterioration and aging in Arabidopsis.
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Genomic context

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See PLDALPHA1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 4

Sequence:: Chromosome: 3; NC_003074.8 (5330194..5333745)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphatidic acid modulates MPK3- and MPK6-mediated hypoxia signaling in Arabidopsis.
Title: Phosphatidic acid modulates MPK3- and MPK6-mediated hypoxia signaling in Arabidopsis.
PLDalpha1 and GPA1 are involved in the stomatal closure induced by Oridonin in Arabidopsis thaliana.
Title: PLDα1 and GPA1 are involved in the stomatal closure induced by Oridonin in Arabidopsis thaliana.
Crystal structure of plant PLDalpha1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D.
Title: Crystal structure of plant PLDα1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D.
Arabidopsis NRT1.2 interacts with the PHOSPHOLIPASE Dalpha1 (PLDalpha1) to positively regulate seed germination and seedling development in response to ABA treatment.
Title: Arabidopsis NRT1.2 interacts with the PHOSPHOLIPASE Dα1 (PLDα1) to positively regulate seed germination and seedling development in response to ABA treatment.
Phospholipase Dalpha1 mediates the high-Mg(2) (+) stress response partially through regulation of K(+) homeostasis.
Title: Phospholipase Dα1 mediates the high-Mg(2)(+) stress response partially through regulation of K(+) homeostasis.
The results demonstrate that PLDalpha1 and PLDdelta oppositely modulate basal, post-penetration resistance against powdery mildew through a non-canonical mechanism that is independent of EDS1/PAD4, SA, and JA.
Title: Arabidopsis phospholipase Dα1 and Dδ oppositely modulate EDS1- and SA-independent basal resistance against adapted powdery mildew.
At3g15730 (phospholipase D alpha 1) role in the stomatal closure and hydrogen sulfide signal transduction.
Title: Hydrogen Sulfide Increases Production of NADPH Oxidase-Dependent Hydrogen Peroxide and Phospholipase D-Derived Phosphatidic Acid in Guard Cell Signaling.
PLDalpha1-mediated phosphatidic acid formation modulates desiccation sensitivity as applying its inhibitor improved seed desiccation tolerance and its suppression in protoplasts enhanced survival under dehydration.
Title: Phospholipase Dα1-mediated phosphatidic acid change is a key determinant of desiccation-induced viability loss in seeds.
In Arabidopsis thaliana, PLDalpha1/PA might regulate cell development by modulating microtubule organization in an activity-dependent manner.
Title: Arabidopsis phospholipase D alpha 1-derived phosphatidic acid regulates microtubule organization and cell development under microtubule-interacting drugs treatment.
The phospholipase Dalpha1 protein is a key component and modulator of the G-protein complex in affecting a subset of signaling pathways.
Title: The role of PLDα1 in providing specificity to signal-response coupling by heterotrimeric G-protein components in Arabidopsis.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_112443.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acylphosphatidylethanolamine-specific phospholipase D activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase D activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase D activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within abscisic acid-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fatty acid metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within leaf shaping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of abscisic acid-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of stomatal movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seed germination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: phospholipase D alpha 1

NP_188194.1

phospholipase D alpha 1 (PLDALPHA1); FUNCTIONS IN: phospholipase D activity, phosphatidylinositol-4,5-bisphosphate binding; INVOLVED IN: response to cadmium ion, fatty acid metabolic process, seed germination, regulation of stomatal movement, positive regulation of abscisic acid mediated signaling pathway; LOCATED IN: in 6 components; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Phospholipase D (InterPro:IPR015679), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Phospholipase D/Transphosphatidylase (InterPro:IPR001736), C2 calcium-dependent membrane targeting (InterPro:IPR000008), Phospholipase D, plant (InterPro:IPR011402); BEST Arabidopsis thaliana protein match is: phospholipase D alpha 2 (TAIR:AT1G52570.1); Has 2073 Blast hits to 1588 proteins in 412 species: Archae - 0; Bacteria - 593; Metazoa - 344; Fungi - 417; Plants - 575; Viruses - 0; Other Eukaryotes - 144 (source: NCBI BLink).