ABCG11 white-brown complex-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ABCG11
Official Full Name: white-brown complex-like protein
Primary source: TAIR:AT1G17840
Locus tag: AT1G17840
See related: Araport:AT1G17840
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA WHITE-BROWN COMPLEX HOMOLOG PROTEIN 11; AtABCG11; ATP-binding cassette G11; ATWBC11; COF1; CUTICULAR DEFECT AND ORGAN FUSION 1; DESPERADO; DSO; F2H15.7; F2H15_7; WBC11; white-brown complex homolog protein 11
Summary: Encodes a plasma membrane-localized ATP-binding cassette transporter, that is required for cutin transport to the extracellular matrix.
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Genomic context

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See ABCG11 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 10

Sequence:: Chromosome: 1; NC_003070.9 (6142402..6146521)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ABCG9, ABCG11 and ABCG14 are expressed in the vascular system. Mutations are responsible for defects in plant growth and affect vascular patterning.
Title: ABCG9, ABCG11 and ABCG14 ABC transporters are required for vascular development in Arabidopsis.
ABCG11 and ABCG12 form a heterodimer. ABCG11 trafficking to the plasma membrane is independent of ABCG12.
Title: Arabidopsis ABCG transporters, which are required for export of diverse cuticular lipids, dimerize in different combinations.
The dso-4 phenotypes corresponded to the strong DSO/ABCG11 gene expression in the embryo epidermis as well as in the endosperm tissues of the developing seeds. Moreover, the DSO/ABCG11 protein displayed polar localization in the embryo protoderm.
Title: The Arabidopsis DSO/ABCG11 transporter affects cutin metabolism in reproductive organs and suberin in roots.
wax and cutin monomers were both reduced in the atwbc11 mutant. AtWBC11 was widely expressed in aerial organs. Interestingly, we found that the expression was light dependent, and the phytohormone ABA up-regulated AtWBC11 expression
Title: An ABC transporter gene of Arabidopsis thaliana, AtWBC11, is involved in cuticle development and prevention of organ fusion.
findings show that DESPERADO (AtWBC11), encoding a plasma membrane-localized ATP-binding cassette transporter, is required for cutin transport to the extracellular matrix
Title: The Arabidopsis DESPERADO/AtWBC11 transporter is required for cutin and wax secretion.
results show that WBC11 (At1g17840) functions in secretion of surface waxes, possibly by interacting with CER5; however, unlike ABCG12/CER5, ABCG11/WBC11 is important to the normal process of cutin formation
Title: Characterization of Arabidopsis ABCG11/WBC11, an ATP binding cassette (ABC) transporter that is required for cuticular lipid secretion.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_101647.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables efflux transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables fatty acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables fatty acid transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cotyledon vascular tissue pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cotyledon vascular tissue pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cutin transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cutin transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fatty acid transport	TAS Traceable Author Statement more info	PubMed
involved_in response to abscisic acid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to salt stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to wounding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within stem vascular tissue pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in suberin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IPI Inferred from Physical Interaction more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: white-brown complex-like protein

NP_173226.2

white-brown complex homolog protein 11 (WBC11); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances, fatty acid transporter activity; INVOLVED IN: cutin transport, fatty acid transport; LOCATED IN: plasma membrane, external side of plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC-2 type transporter (InterPro:IPR013525), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: ABC-2 type transporter family protein (TAIR:AT3G21090.1); Has 367567 Blast hits to 338203 proteins in 4071 species: Archae - 6733; Bacteria - 294034; Metazoa - 7509; Fungi - 6244; Plants - 5251; Viruses - 10; Other Eukaryotes - 47786 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

6142402..6146521

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101647.5 → NP_173226.2 white-brown complex-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_173226.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8RXN0, Q9LMU4

UniProtKB/TrEMBL

A0A178WKJ6, A0A5S9UVZ2

Conserved Domains (1) summary

TIGR00955
Location:66 → 601

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein