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    NIP1;2 NOD26-like intrinsic protein 1;2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827626, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NIP1;2
    Official Full Name
    NOD26-like intrinsic protein 1;2
    Primary source
    TAIR:AT4G18910
    Locus tag
    AT4G18910
    See related
    Araport:AT4G18910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATNLM2; F13C5.80; F13C5_80; NLM2; NOD26-like intrinsic protein 1;2; NOD26-LIKE INTRINSIC PROTEIN 2
    Summary
    Encodes an aquaporin homolog. Functions in arsenite transport and tolerance.When expressed in yeast cells can conduct hydrogen peroxide into those cells.
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    Genomic context

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    See NIP1;2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (10366044..10368510)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene histone acetyltransferase (DUF1264) Neighboring gene RNA ligase/cyclic nucleotide phosphodiesterase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The roles of selectivity filters in determining aluminum transport by AtNIP1;2. Wang Y, et al. Plant Signal Behav, 2021 Dec 2. PMID 34709126, Free PMC Article
    2. Aluminum-activated root malate and citrate exudation is independent of NIP1;2-facilitated root-cell-wall aluminum removal in Arabidopsis. Wang Y, et al. Plant Signal Behav, 2018 Jan 2. PMID 29293394, Free PMC Article
    3. NIP1;2 is a plasma membrane-localized transporter mediating aluminum uptake, translocation, and tolerance in Arabidopsis. Wang Y, et al. Proc Natl Acad Sci U S A, 2017 May 9. PMID 28439024, Free PMC Article
    4. An exclusion mechanism is epistatic to an internal detoxification mechanism in aluminum resistance in Arabidopsis. Wang Y, et al. BMC Plant Biol, 2020 Mar 18. PMID 32188405, Free PMC Article
    5. NIP1;1, an aquaporin homolog, determines the arsenite sensitivity of Arabidopsis thaliana. Kamiya T, et al. J Biol Chem, 2009 Jan 23. PMID 19029297

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The roles of selectivity filters in determining aluminum transport by AtNIP1;2.
      Title: The roles of selectivity filters in determining aluminum transport by AtNIP1;2.
    2. An exclusion mechanism is epistatic to an internal detoxification mechanism in aluminum resistance in Arabidopsis.
      Title: An exclusion mechanism is epistatic to an internal detoxification mechanism in aluminum resistance in Arabidopsis.
    3. NIP1;2-mediated Aluminum (Al) uptake system, is critical for Al resistance in Arabidopsis.
      Title: Aluminum-activated root malate and citrate exudation is independent of NIP1;2-facilitated root-cell-wall aluminum removal in Arabidopsis.
    4. these findings reveal a critical linkage between the previously identified Al exclusion mechanism based on root malate release and an internal Al tolerance mechanism identified here through the coordinated function of NIP1;2 and ALMT1, which is required for Al removal from the root cell wall, root-to-shoot Al translocation, and overall Al tolerance in Arabidopsis.
      Title: NIP1;2 is a plasma membrane-localized transporter mediating aluminum uptake, translocation, and tolerance in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001341307.1
    NM_118008.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables arsenite transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables water channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within arsenite transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hydrogen peroxide transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NOD26-like intrinsic protein 1;2
    NP_193626.1
    • NOD26-like intrinsic protein 1;2 (NIP1;2); FUNCTIONS IN: water channel activity, arsenite transmembrane transporter activity; INVOLVED IN: transport, hydrogen peroxide transmembrane transport, response to arsenic, arsenite transport; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Major intrinsic protein, conserved site (InterPro:IPR022357), Aquaporin (InterPro:IPR012269), Major intrinsic protein (InterPro:IPR000425); BEST Arabidopsis thaliana protein match is: NOD26-like major intrinsic protein 1 (TAIR:AT4G19030.1); Has 10753 Blast hits to 10647 proteins in 2223 species: Archae - 110; Bacteria - 5339; Metazoa - 1367; Fungi - 450; Plants - 2101; Viruses - 4; Other Eukaryotes - 1382 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10366044..10368510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118008.4 → NP_193626.1  NOD26-like intrinsic protein 1;2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193626.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49406, Q8LFP7
      UniProtKB/TrEMBL
      A0A178UV35, A0A5S9XU64
      Conserved Domains (1) summary
      PLN00184
      Location:1 → 293
      PLN00184; aquaporin NIP1; Provisional

    2. NM_001341307.1 → NP_001327999.1  NOD26-like intrinsic protein 1;2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B3A0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LFP7.2

    Gene LinkOut

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