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    MSI3 Transducin family protein / WD-40 repeat family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829657, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MSI3
    Official Full Name
    Transducin family protein / WD-40 repeat family protein
    Primary source
    TAIR:AT4G35050
    Locus tag
    AT4G35050
    See related
    Araport:AT4G35050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    M4E13.110; M4E13_110; MULTICOPY SUPPRESSOR OF IRA1 3; NFC3; NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR GROUP C 3
    Summary
    Encodes a WD-40 repeat protein similar to yeast MSI1. The predicted protein has a DWD motif. It can bind to DDB1a in Y2H assays, and DDB1b in co-IP assays, and may be involved in the formation of a CUL4-based E3 ubiquitin ligase
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    Genomic context

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    See MSI3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Sequence:
    Chromosome: 4; NC_003075.7 (16682580..16684928, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene RAC-like 3 Neighboring gene Protein kinase superfamily protein Neighboring gene uncharacterized protein Neighboring gene Basic-leucine zipper (bZIP) transcription factor family protein Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene SBP (S-ribonuclease binding protein) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dual Recognition of H3K4me3 and DNA by the ISWI Component ARID5 Regulates the Floral Transition in Arabidopsis. Tan LM, et al. Plant Cell, 2020 Jul. PMID 32358072, Free PMC Article
    2. Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. Lee JH, et al. Plant Cell, 2008 Jan. PMID 18223036, Free PMC Article
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119671.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of ISWI-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Transducin family protein / WD-40 repeat family protein
    NP_195231.1
    • MULTICOPY SUPPRESSOR OF IRA1 3 (MSI3); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), Histone-binding protein RBBP4 (InterPro:IPR022052), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin family protein / WD-40 repeat family protein (TAIR:AT2G16780.1); Has 37885 Blast hits to 23592 proteins in 711 species: Archae - 24; Bacteria - 3738; Metazoa - 15273; Fungi - 8747; Plants - 5038; Viruses - 0; Other Eukaryotes - 5065 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16682580..16684928 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119671.3 → NP_195231.1  Transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195231.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22469, O49612
      UniProtKB/TrEMBL
      A0A5S9Y0Y7, Q5HZ33, Q84WQ9
      Conserved Domains (3) summary
      sd00039
      Location:121 → 167
      7WD40; WD40 repeat [structural motif]
      pfam12265
      Location:17 → 89
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      cl29593
      Location:156 → 394
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22469.2

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