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    HA4 H[+]-ATPase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823950, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HA4
    Official Full Name
    H[+]-ATPase 4
    Primary source
    TAIR:AT3G47950
    Locus tag
    AT3G47950
    See related
    Araport:AT3G47950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AHA4; H(+)-ATPase 4
    Summary
    mutant has Slight reduction in root and shoot growth; Exaggerated defects in salt stress; Plasma Membrane H+ ATPase
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    Genomic context

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    See HA4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    21
    Sequence:
    Chromosome: 3; NC_003074.8 (17692666..17697999)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene L-galactono-1,4-lactone dehydrogenase Neighboring gene DNAJ heat shock family protein Neighboring gene ncRNA Neighboring gene Major facilitator superfamily protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for a role in growth and salt resistance of a plasma membrane H+-ATPase in the root endodermis. Vitart V, et al. Plant J, 2001 Aug. PMID 11532165
    2. Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry. Nühse TS, et al. Mol Cell Proteomics, 2003 Nov. PMID 14506206
    3. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
    4. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article
    5. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001339341.1
    NM_114664.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables P-type proton-exporting transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proton export across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    H[+]-ATPase 4
    NP_190378.2
    • H(+)-ATPase 4 (HA4); FUNCTIONS IN: ATPase activity, hydrogen-exporting ATPase activity, phosphorylative mechanism; INVOLVED IN: response to salt stress; LOCATED IN: plasma membrane; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type cation-transporter, N-terminal (InterPro:IPR004014), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, H+ transporting proton pump (InterPro:IPR000695), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type, plasma-membrane proton-efflux (InterPro:IPR006534), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: H(+)-ATPase 11 (TAIR:AT5G62670.1); Has 37029 Blast hits to 33095 proteins in 3202 species: Archae - 699; Bacteria - 23601; Metazoa - 3987; Fungi - 2466; Plants - 1918; Viruses - 3; Other Eukaryotes - 4355 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      17692666..17697999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114664.4 → NP_190378.2  H[+]-ATPase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190378.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GXR3, Q9SU58
      UniProtKB/TrEMBL
      A0A178VFQ4, A0A5S9XIT6
      Conserved Domains (1) summary
      TIGR01647
      Location:40 → 816
      ATPase-IIIA_H; plasma-membrane proton-efflux P-type ATPase

    2. NM_001339341.1 → NP_001325714.1  H[+]-ATPase 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GXR3, Q9SU58
      UniProtKB/TrEMBL
      A0A178VFQ4, A0A5S9XIT6
      Conserved Domains (1) summary
      TIGR01647
      Location:40 → 816
      ATPase-IIIA_H; plasma-membrane proton-efflux P-type ATPase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SU58.2

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