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    EDS1 alpha/beta-Hydrolases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823964, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EDS1
    Official Full Name
    alpha/beta-Hydrolases superfamily protein
    Primary source
    TAIR:AT3G48090
    Locus tag
    AT3G48090
    See related
    Araport:AT3G48090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATEDS1; EDS1 PROTEIN; enhanced disease susceptibility 1
    Summary
    Component of R gene-mediated disease resistance in Arabidopsis thaliana with homology to eukaryotic lipases.
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    Genomic context

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    See EDS1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (17755329..17758147, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene BAH and TFIIS domain-containing protein Neighboring gene RING/U-box superfamily protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene response regulator 5 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1. Johanndrees O, et al. Plant Physiol, 2023 Jan 2. PMID 36227084, Free PMC Article
    2. EDS1, an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases. Falk A, et al. Proc Natl Acad Sci U S A, 1999 Mar 16. PMID 10077677, Free PMC Article
    3. The role of EDS1 (enhanced disease susceptibility) during singlet oxygen-mediated stress responses of Arabidopsis. Ochsenbein C, et al. Plant J, 2006 Aug. PMID 16790029
    4. Enhanced disease susceptibility 1 and salicylic acid act redundantly to regulate resistance gene-mediated signaling. Venugopal SC, et al. PLoS Genet, 2009 Jul. PMID 19578402, Free PMC Article
    5. Salicylic acid antagonism of EDS1-driven cell death is important for immune and oxidative stress responses in Arabidopsis. Straus MR, et al. Plant J, 2010 May 1. PMID 20163553

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cold priming on pathogen susceptibility in the Arabidopsis eds1 mutant background requires a functional stromal Ascorbate Peroxidase.
      Title: Cold priming on pathogen susceptibility in the Arabidopsis eds1 mutant background requires a functional stromal Ascorbate Peroxidase.
    2. Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1.
      Title: Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1.
    3. The BZR1-EDS1 module regulates plant growth-defense coordination.
      Title: The BZR1-EDS1 module regulates plant growth-defense coordination.
    4. The EDS1-PAD4-ADR1 node mediates Arabidopsis pattern-triggered immunity.
      Title: The EDS1-PAD4-ADR1 node mediates Arabidopsis pattern-triggered immunity.
    5. The immune components ENHANCED DISEASE SUSCEPTIBILITY 1 and PHYTOALEXIN DEFICIENT 4 are required for cell death caused by overaccumulation of ceramides in Arabidopsis.
      Title: The immune components ENHANCED DISEASE SUSCEPTIBILITY 1 and PHYTOALEXIN DEFICIENT 4 are required for cell death caused by overaccumulation of ceramides in Arabidopsis.
    6. Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity.
      Title: Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity.
    7. EDS1 is a monomeric protein when not part of a heterodimer with its signaling partners, PAD4 or SAG101.
      Title: Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation.
    8. AtEDS1-AtSAG101 functions together with N REQUIRED GENE1 (AtNRG1) coiled-coil domain helper NLRs as a coevolved TNL cell death-signaling module.
      Title: A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors.
    9. DELLA and EDS1 Form a Feedback Regulatory Module to Fine-Tune Plant Growth-Defense Tradeoff in Arabidopsis
      Title: DELLA and EDS1 Form a Feedback Regulatory Module to Fine-Tune Plant Growth-Defense Tradeoff in Arabidopsis.
    10. PBS3 Protects EDS1 from Proteasome-Mediated Degradation in Plant Immunity
      Title: PBS3 Protects EDS1 from Proteasome-Mediated Degradation in Plant Immunity.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001035752.1
    NM_114678.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within aerenchyma formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf abscission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within plant-type hypersensitive response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plant-type hypersensitive response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of hydrogen peroxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to singlet oxygen IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within systemic acquired resistance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within systemic acquired resistance, salicylic acid mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha/beta-Hydrolases superfamily protein
    NP_001030829.1
    • enhanced disease susceptibility 1 (EDS1); CONTAINS InterPro DOMAIN/s: Lipase, class 3 (InterPro:IPR002921); BEST Arabidopsis thaliana protein match is: alpha/beta-Hydrolases superfamily protein (TAIR:AT3G48080.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_190392.1
    • enhanced disease susceptibility 1 (EDS1); CONTAINS InterPro DOMAIN/s: Lipase, class 3 (InterPro:IPR002921); BEST Arabidopsis thaliana protein match is: alpha/beta-Hydrolases superfamily protein (TAIR:AT3G48080.1); Has 536 Blast hits to 485 proteins in 45 species: Archae - 0; Bacteria - 4; Metazoa - 2; Fungi - 2; Plants - 491; Viruses - 0; Other Eukaryotes - 37 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      17755329..17758147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114678.4 → NP_190392.1  alpha/beta-Hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190392.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFM5, Q9SU72
      UniProtKB/TrEMBL
      B2BDD6
      Conserved Domains (1) summary
      pfam01764
      Location:81 → 197
      Lipase_3; Lipase (class 3)

    2. NM_001035752.1 → NP_001030829.1  alpha/beta-Hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030829.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B2BDD6
      Conserved Domains (1) summary
      cl21494
      Location:8 → 89
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SU72.1

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