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    GLR3.6 glutamate receptor 3.6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824311, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLR3.6
    Official Full Name
    glutamate receptor 3.6
    Primary source
    TAIR:AT3G51480
    Locus tag
    AT3G51480
    See related
    Araport:AT3G51480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGLR3.6; glutamate receptor 3.6
    Summary
    member of Putative ligand-gated ion channel subunit family
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    Genomic context

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    See GLR3.6 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (19100676..19104844)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Phosphoinositide phosphatase family protein Neighboring gene Protein phosphatase 2C family protein Neighboring gene miscRNA Neighboring gene tonoplast monosaccharide transporter3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two glutamate- and pH-regulated Ca(2+) channels are required for systemic wound signaling in Arabidopsis. Shao Q, et al. Sci Signal, 2020 Jul 14. PMID 32665412
    2. The Arabidopsis glutamate receptor-like gene GLR3.6 controls root development by repressing the Kip-related protein gene KRP4. Singh SK, et al. J Exp Bot, 2016 Mar. PMID 26773810
    3. GLUTAMATE RECEPTOR-LIKE genes mediate leaf-to-leaf wound signalling. Mousavi SA, et al. Nature, 2013 Aug 22. PMID 23969459
    4. New roles for the GLUTAMATE RECEPTOR-LIKE 3.3, 3.5, and 3.6 genes as on/off switches of wound-induced systemic electrical signals. Salvador-Recatalà V. Plant Signal Behav, 2016. PMID 26966923, Free PMC Article
    5. Inter-subunit interactions between glutamate-like receptors in Arabidopsis. Price MB, et al. Plant Signal Behav, 2013. PMID 24300102, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two glutamate- and pH-regulated Ca(2+) channels are required for systemic wound signaling in Arabidopsis.
      Title: Two glutamate- and pH-regulated Ca(2+) channels are required for systemic wound signaling in Arabidopsis.
    2. GLR3.3 and GLR3.6 function as on switches for the propagation of wound-induced potentials beyond the wounded leaf, while GLR3.5 functions as an off switch that prevents the propagation of wound-induced electrical potentials to distal, non-neighbor leaves.
      Title: New roles for the GLUTAMATE RECEPTOR-LIKE 3.3, 3.5, and 3.6 genes as on/off switches of wound-induced systemic electrical signals.
    3. AtGLR3.6 is required for primary and lateral root development, and KRP4 functions as a downstream signaling element in Arabidopsis thaliana.
      Title: The Arabidopsis glutamate receptor-like gene GLR3.6 controls root development by repressing the Kip-related protein gene KRP4.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001339516.1
    NM_001339517.1
    NM_001339518.1
    NM_115007.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables intracellularly ligand-gated monoatomic ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in calcium-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell-cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to amino acid stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in induced systemic resistance, jasmonic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutamate receptor 3.6
    NP_190716.3
    • glutamate receptor 3.6 (GLR3.6); FUNCTIONS IN: intracellular ligand-gated ion channel activity; INVOLVED IN: cellular calcium ion homeostasis, response to light stimulus; LOCATED IN: endomembrane system, integral to membrane, membrane; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Extracellular solute-binding protein, family 3 (InterPro:IPR001638), Ionotropic glutamate receptor (InterPro:IPR001320), Extracellular ligand-binding receptor (InterPro:IPR001828), GPCR, family 3, gamma-aminobutyric acid receptor, type B (InterPro:IPR002455), Glutamate receptor-related (InterPro:IPR015683), Ionotropic glutamate-like receptor, plant (InterPro:IPR017103); BEST Arabidopsis thaliana protein match is: glutamate receptor 3.3 (TAIR:AT1G42540.1); Has 6142 Blast hits to 5992 proteins in 427 species: Archae - 49; Bacteria - 557; Metazoa - 4617; Fungi - 0; Plants - 640; Viruses - 0; Other Eukaryotes - 279 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      19100676..19104844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115007.4 → NP_190716.3  glutamate receptor 3.6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190716.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84W41, Q9SD01
      UniProtKB/TrEMBL
      A0A178VDF9
      Conserved Domains (4) summary
      cd06366
      Location:31 → 417
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      cd13686
      Location:458 → 797
      GluR_Plant; Plant glutamate receptor domain; the type 2 periplasmic binding protein fold
      pfam00060
      Location:578 → 830
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:49 → 399
      ANF_receptor; Receptor family ligand binding region

    2. NM_001339516.1 → NP_001326367.1  glutamate receptor 3.6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VDF9, A0A1I9LP22

    3. NM_001339517.1 → NP_001326368.1  glutamate receptor 3.6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VDF9, A0A1I9LP23

    4. NM_001339518.1 → NP_001326369.1  glutamate receptor 3.6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84W41, Q9SD01
      UniProtKB/TrEMBL
      A0A178VDF9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84W41.1

    Gene LinkOut

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