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    DFD DHFS-FPGS homolog D [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824729, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DFD
    Official Full Name
    DHFS-FPGS homolog D
    Primary source
    TAIR:AT3G55630
    Locus tag
    AT3G55630
    See related
    Araport:AT3G55630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATDFD; DHFS-FPGS homolog D; folylpolyglutamate synthetase 3; FPGS3
    Summary
    Encodes one of the three folylpolyglutamate synthetase isoforms (FPGSs): FPGS1 (At5g05980, plastidic), FPGS2 (At3g10160, mitochondrial) and FPGS3 (At3g55630, cytosolic).
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    Genomic context

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    See DFD in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    15
    Sequence:
    Chromosome: 3; NC_003074.8 (20636607..20639492)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Mitochondrial glycoprotein family protein Neighboring gene delta 1-pyrroline-5-carboxylate synthase 2 Neighboring gene Translation initiation factor IF6 Neighboring gene Mitochondrial substrate carrier family protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The folylpolyglutamate synthetase plastidial isoform is required for postembryonic root development in Arabidopsis. Srivastava AC, et al. Plant Physiol, 2011 Mar. PMID 21233333, Free PMC Article
    2. Functional analysis of folate polyglutamylation and its essential role in plant metabolism and development. Mehrshahi P, et al. Plant J, 2010 Oct. PMID 21070407
    3. Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana. Ravanel S, et al. Proc Natl Acad Sci U S A, 2001 Dec 18. PMID 11752472, Free PMC Article
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtDFB is the predominant FPGS isoform that generates polyglutamylated folate cofactors to support C1 metabolism.
      Title: The folylpolyglutamate synthetase plastidial isoform is required for postembryonic root development in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001339737.1
    NM_001339738.1
    NM_001339739.1
    NM_115421.4
    NM_180686.2
    NM_180687.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tetrahydrofolylpolyglutamate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tetrahydrofolylpolyglutamate synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables tetrahydrofolylpolyglutamate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within one-carbon metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in tetrahydrofolylpolyglutamate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tetrahydrofolylpolyglutamate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DHFS-FPGS homolog D
    NP_567026.3
    • DHFS-FPGS homolog D (DFD); CONTAINS InterPro DOMAIN/s: Folylpolyglutamate synthetase, conserved site (InterPro:IPR018109), Mur ligase, central (InterPro:IPR013221), Mur ligase, C-terminal (InterPro:IPR004101), Folylpolyglutamate synthetase (InterPro:IPR001645); BEST Arabidopsis thaliana protein match is: DHFS-FPGS homolog B (TAIR:AT5G05980.2); Has 7708 Blast hits to 7704 proteins in 2536 species: Archae - 43; Bacteria - 4842; Metazoa - 167; Fungi - 350; Plants - 132; Viruses - 0; Other Eukaryotes - 2174 (source: NCBI BLink).
    NP_851017.1
    • DHFS-FPGS homolog D (DFD); CONTAINS InterPro DOMAIN/s: Folylpolyglutamate synthetase, conserved site (InterPro:IPR018109), Mur ligase, central (InterPro:IPR013221), Mur ligase, C-terminal (InterPro:IPR004101), Folylpolyglutamate synthetase (InterPro:IPR001645); BEST Arabidopsis thaliana protein match is: DHFS-FPGS homolog B (TAIR:AT5G05980.2); Has 7683 Blast hits to 7678 proteins in 2538 species: Archae - 43; Bacteria - 4846; Metazoa - 166; Fungi - 352; Plants - 132; Viruses - 0; Other Eukaryotes - 2144 (source: NCBI BLink).
    NP_851018.1
    • DHFS-FPGS homolog D (DFD); CONTAINS InterPro DOMAIN/s: Mur ligase, central (InterPro:IPR013221), Mur ligase, C-terminal (InterPro:IPR004101), Folylpolyglutamate synthetase (InterPro:IPR001645); BEST Arabidopsis thaliana protein match is: DHFS-FPGS homolog B (TAIR:AT5G05980.2); Has 7671 Blast hits to 7667 proteins in 2537 species: Archae - 43; Bacteria - 4845; Metazoa - 167; Fungi - 348; Plants - 132; Viruses - 0; Other Eukaryotes - 2136 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20636607..20639492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001339736.1 → NP_001327282.1  DHFS-FPGS homolog D [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LRU3, A0A7G2ERJ6

    2. NM_115421.4 → NP_567026.3  DHFS-FPGS homolog D [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567026.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IWY4, Q8LD20, Q8W035, Q93Y54, Q9M059
      UniProtKB/TrEMBL
      A0A178V748, A0A7G2ERJ6
      Conserved Domains (1) summary
      PLN02881
      Location:1 → 492
      PLN02881; tetrahydrofolylpolyglutamate synthase

    3. NM_180686.2 → NP_851017.1  DHFS-FPGS homolog D [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2ERJ6
      Conserved Domains (2) summary
      PLN02881
      Location:1 → 470
      PLN02881; tetrahydrofolylpolyglutamate synthase
      pfam08245
      Location:63 → 245
      Mur_ligase_M; Mur ligase middle domain

    4. NM_001339737.1 → NP_001327281.1  DHFS-FPGS homolog D [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LRU5

    5. NM_001339738.1 → NP_001327280.1  DHFS-FPGS homolog D [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LRU3, A0A7G2ERJ6

    6. NM_180687.2 → NP_851018.1  DHFS-FPGS homolog D [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851018.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2ERJ6
      Conserved Domains (2) summary
      PLN02881
      Location:1 → 491
      PLN02881; tetrahydrofolylpolyglutamate synthase
      pfam08245
      Location:63 → 266
      Mur_ligase_M; Mur ligase middle domain

    7. NM_001339739.1 → NP_001327279.1  DHFS-FPGS homolog D [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LRU3, A0A7G2ERJ6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W035.1

    Gene LinkOut

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