U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CAN Ca-2+ dependent nuclease [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824783, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CAN
    Official Full Name
    Ca-2+ dependent nuclease
    Primary source
    TAIR:AT3G56170
    Locus tag
    AT3G56170
    See related
    Araport:AT3G56170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Ca-2+ dependent nuclease; calcium dependent nuclease 1; CAN1
    Summary
    Encodes a calcium-dependent nuclease with similarity to staphylococcal nuclease.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CAN in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (20842145..20844537)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3C Neighboring gene Sodium Bile acid symporter family Neighboring gene LURP-one-like protein (DUF567) Neighboring gene alpha-soluble NSF attachment protein 2 Neighboring gene Transmembrane amino acid transporter family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular cloning of a cDNA encoding a novel Ca(2+)-dependent nuclease of Arabidopsis that is similar to staphylococcal nuclease. Isono K, et al. Biochim Biophys Acta, 2000 Apr 25. PMID 10760589
    2. Plant plasma membrane-bound staphylococcal-like DNases as a novel class of eukaryotic nucleases. Leśniewicz K, et al. BMC Plant Biol, 2012 Oct 26. PMID 23102437, Free PMC Article
    3. Arabidopsis cysteine proteinase inhibitor AtCYSb interacts with a Ca(2+)-dependent nuclease, AtCaN2. Guo K, et al. FEBS Lett, 2013 Nov 1. PMID 24076026
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two Arabidopsis staphylococcal-like nucleases, named CAN1 and CAN2, are anchored to the cell membrane via N-terminal myristoylation and palmitoylation modifications.[CAN1]
      Title: Plant plasma membrane-bound staphylococcal-like DNases as a novel class of eukaryotic nucleases.
    2. AtCaN2, a Ca(2+)-dependent nuclease in Arabidopsis, is transcribed in senescent leaves and stems and interacts with an Arabidopsis cystatin (AtCYSb) in a yeast two-hybrid screen.
      Title: Arabidopsis cysteine proteinase inhibitor AtCYSb interacts with a Ca(2+)-dependent nuclease, AtCaN2.
    3. The protein encoded by AT3G56170 (CAN or CAN1) is a Ca2+-dependent and Zn2+-sensitive, plasma membrane nuclease which degrades ssDNA, dsDNA and RNA at neutral pH. This protein possesses a hybrid structure of its catalytic domain consisting of staphylococcal nuclease-like and tRNA synthetase anticodon binding-like motifs. Expression of CAN1 nuclease correlates with different forms of plant programmed cell death.
      Title: Plant plasma membrane-bound staphylococcal-like DNases as a novel class of eukaryotic nucleases.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    NM_115475.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables nuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Ca-2+ dependent nuclease
    NP_567036.1
    • Ca-2+ dependent nuclease (CAN); FUNCTIONS IN: nuclease activity; INVOLVED IN: N-terminal protein myristoylation; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Staphylococcal nuclease (SNase-like) (InterPro:IPR006021), Staphylococcal nuclease (SNase-like), OB-fold (InterPro:IPR016071), Thermonuclease active site (InterPro:IPR002071); BEST Arabidopsis thaliana protein match is: Staphylococcal nuclease homologue (TAIR:AT2G40410.2); Has 3061 Blast hits to 3061 proteins in 776 species: Archae - 16; Bacteria - 1825; Metazoa - 0; Fungi - 167; Plants - 86; Viruses - 2; Other Eukaryotes - 965 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20842145..20844537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115475.5 → NP_567036.1  Ca-2+ dependent nuclease [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567036.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IZC5, Q9LWC0, Q9LYM4
      UniProtKB/TrEMBL
      A0A178VL52, A0A5S9XL92
      Conserved Domains (1) summary
      pfam00565
      Location:211 → 306
      SNase; Staphylococcal nuclease homolog
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4IZC5.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools