RTM3 RESTRICTED TEV MOVEMENT 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RTM3
Official Full Name: RESTRICTED TEV MOVEMENT 3
Primary source: TAIR:AT3G58350
Locus tag: AT3G58350
See related: Araport:AT3G58350
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: RESTRICTED TEV MOVEMENT 3
Summary: Encodes RTM3 (Restricted Tobacco etch potyvirus Movement), a protein belonging to a protein family of 29 members which has a meprin and TRAF homology (MATH) domain in its N-terminal region and a coiled-coil (CC) domain at its C-terminal end. There are at least three RTMs in Arabidopsis. RTM proteins might form a multiprotein complex in the resistance mechanism to block the long distance movement of potyviruses.
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Genomic context

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See RTM3 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 5

Sequence:: Chromosome: 3; NC_003074.8 (21591409..21592962, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RTM3 protein interacts directly with RTM1 strongly suggests that the restricted TEV movement proteins form a multimeric complex.
Title: A member of a new plant gene family encoding a meprin and TRAF homology (MATH) domain-containing protein is involved in restriction of long distance movement of plant viruses.
RTM proteins might form a multiprotein complex in the resistance mechanism to block the long-distance movement of potyviruses.[RTM3]
Title: RTM3, which controls long-distance movement of potyviruses, is a member of a new plant gene family encoding a meprin and TRAF homology domain-containing protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001339919.1

Supported by ESTs:

NM_115697.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to virus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: RESTRICTED TEV MOVEMENT 3

NP_001319792.1

RESTRICTED TEV MOVEMENT 3 (RTM3); CONTAINS InterPro DOMAIN/s: TRAF-like (InterPro:IPR008974), MATH (InterPro:IPR002083); BEST Arabidopsis thaliana protein match is: TRAF-like family protein (TAIR:AT3G58360.1); Has 797 Blast hits to 693 proteins in 52 species: Archae - 0; Bacteria - 2; Metazoa - 4; Fungi - 33; Plants - 733; Viruses - 0; Other Eukaryotes - 25 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

21591409..21592962 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001339919.1 → NP_001319792.1 RESTRICTED TEV MOVEMENT 3 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

D5K228, Q9M2I1

UniProtKB/TrEMBL

D5K225, D5K226, D5K237, D9UBE0

Conserved Domains (2) summary

cd00121
Location:8 → 135

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

pfam05278
Location:156 → 279

PEARLI-4; Arabidopsis phospholipase-like protein (PEARLI 4)
NM_115697.1 → NP_567063.1 RESTRICTED TEV MOVEMENT 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567063.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D5K228, Q9M2I1

UniProtKB/TrEMBL

D5K225, D5K226, D5K237, D9UBE0

Conserved Domains (2) summary

cd00121
Location:8 → 135

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

pfam05278
Location:156 → 279

PEARLI-4; Arabidopsis phospholipase-like protein (PEARLI 4)