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    FLS1 flavonol synthase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830765, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FLS1
    Official Full Name
    flavonol synthase 1
    Primary source
    TAIR:AT5G08640
    Locus tag
    AT5G08640
    See related
    Araport:AT5G08640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATFLS1; FLAVONOL SYNTHASE; flavonol synthase 1; FLS; T2K12.5
    Summary
    Encodes a flavonol synthase that catalyzes formation of flavonols from dihydroflavonols. Co-expressed with CHI and CHS (qRT-PCR).
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    Genomic context

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    See FLS1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (2803833..2805606)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene DEA(D/H)-box RNA helicase family protein Neighboring gene DDT domain-containing protein Neighboring gene Small GTP-binding protein Neighboring gene D-lactate dehydrogenase (DUF668) Neighboring gene ATP synthase alpha/beta family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Arabidopsis thaliana FLAVONOL SYNTHASE 1 (FLS1) -overexpression plants in response to abiotic stress. Nguyen NH, et al. Plant Physiol Biochem, 2016 Jun. PMID 26990404
    2. In vitro properties of a recombinant flavonol synthase from Arabidopsis thaliana. Prescott AG, et al. Phytochemistry, 2002 Jul. PMID 12126705
    3. Drastic anthocyanin increase in response to PAP1 overexpression in fls1 knockout mutant confers enhanced osmotic stress tolerance in Arabidopsis thaliana. Lee WJ, et al. Plant Cell Rep, 2016 Nov. PMID 27562381
    4. Generation and characterisation of an Arabidopsis thaliana f3h/fls1/ans triple mutant that accumulates eriodictyol derivatives. Schilbert HM, et al. BMC Plant Biol, 2024 Feb 9. PMID 38331743, Free PMC Article
    5. Flavonols modulate lateral root emergence by scavenging reactive oxygen species in Arabidopsis thaliana. Chapman JM, et al. J Biol Chem, 2021 Jan-Jun. PMID 33839683, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Generation and characterisation of an Arabidopsis thaliana f3h/fls1/ans triple mutant that accumulates eriodictyol derivatives.
      Title: Generation and characterisation of an Arabidopsis thaliana f3h/fls1/ans triple mutant that accumulates eriodictyol derivatives.
    2. Flavonols modulate lateral root emergence by scavenging reactive oxygen species in Arabidopsis thaliana.
      Title: Flavonols modulate lateral root emergence by scavenging reactive oxygen species in Arabidopsis thaliana.
    3. double mutant plants that harbor fls1kknock out in the pap1-D background (i.e., pap1-D/fls1ko plants) were generated, to examine whether anthocyanins can be further enhanced by blocking flavonol biosynthesis under PAP1 overexpression.
      Title: Drastic anthocyanin increase in response to PAP1 overexpression in fls1 knockout mutant confers enhanced osmotic stress tolerance in Arabidopsis thaliana.
    4. Overexpression of FLS1 (FLS1-OX) not only altered seed coat color (resulting in a light brown color), but also affected flavonoid accumulation. Whereas fls1-3 mutants accumulated higher anthocyanin levels, FLS1-OX seedlings had lower levels than those of the wild-type.
      Title: Characterization of Arabidopsis thaliana FLAVONOL SYNTHASE 1 (FLS1) -overexpression plants in response to abiotic stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203337.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables flavanone 3-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavonol synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within flavonoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    flavonol synthase 1
    NP_001190266.1
    • flavonol synthase 1 (FLS1); CONTAINS InterPro DOMAIN/s: Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: flavonol synthase 3 (TAIR:AT5G63590.1).
    NP_196481.1
    • flavonol synthase 1 (FLS1); CONTAINS InterPro DOMAIN/s: Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: flavonol synthase 3 (TAIR:AT5G63590.1); Has 8476 Blast hits to 8432 proteins in 992 species: Archae - 0; Bacteria - 1104; Metazoa - 92; Fungi - 925; Plants - 4948; Viruses - 0; Other Eukaryotes - 1407 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2803833..2805606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120951.3 → NP_196481.1  flavonol synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196481.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04730, O04731, O04732, O04830, O04831, O04832, Q96330
      UniProtKB/TrEMBL
      A0A178UE53, A0A384L0E6, B1GV57, B1GV59, B7SFQ1
      Conserved Domains (1) summary
      PLN02704
      Location:1 → 335
      PLN02704; flavonol synthase

    2. NM_001203337.1 → NP_001190266.1  flavonol synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190266.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04730, O04731, O04732, O04830, O04831, O04832, Q96330
      UniProtKB/TrEMBL
      A0A178UE53, A0A384L0E6, B1GV57, B1GV59, B7SFQ1
      Conserved Domains (1) summary
      PLN02704
      Location:1 → 335
      PLN02704; flavonol synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96330.1

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