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    GSTF12 glutathione S-transferase phi 12 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831586, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GSTF12
    Official Full Name
    glutathione S-transferase phi 12
    Primary source
    TAIR:AT5G17220
    Locus tag
    AT5G17220
    See related
    Araport:AT5G17220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA GLUTATHIONE S-TRANSFERASE PHI 12; ATGSTF12; GLUTATHIONE S-TRANSFERASE 26; glutathione S-transferase phi 12; GST26; MKP11.22; MKP11_22; TRANSPARENT TESTA 19; TT19
    Summary
    Encodes glutathione transferase belonging to the phi class of GSTs. Naming convention according to Wagner et al. (2002). Mutants display no pigments on leaves and stems. Likely to function as a carrier to transport anthocyanin from the cytosol to tonoplasts.
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    Genomic context

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    See GSTF12 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (5658416..5659661)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Pectin lyase-like superfamily protein Neighboring gene transmembrane protein, putative (DUF1218) Neighboring gene PHYTOENE SYNTHASE Neighboring gene SET domain group 40 Neighboring gene Alkaline-phosphatase-like family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of an anthocyanin-related glutathione S-transferase gene in cyclamen. Kitamura S, et al. J Plant Physiol, 2012 Apr 15. PMID 22251797
    2. Arabidopsis TT19 functions as a carrier to transport anthocyanin from the cytosol to tonoplasts. Sun Y, et al. Mol Plant, 2012 Mar. PMID 22201047
    3. The Arabidopsis tt19-4 mutant differentially accumulates proanthocyanidin and anthocyanin through a 3' amino acid substitution in glutathione S-transferase. Li X, et al. Plant Cell Environ, 2011 Mar. PMID 21054438
    4. Metabolic profiling and cytological analysis of proanthocyanidins in immature seeds of Arabidopsis thaliana flavonoid accumulation mutants. Kitamura S, et al. Plant J, 2010 May 1. PMID 20180920
    5. Tapetosomes in Brassica tapetum accumulate endoplasmic reticulum-derived flavonoids and alkanes for delivery to the pollen surface. Hsieh K, et al. Plant Cell, 2007 Feb. PMID 17307923, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TT19 is a carrier protein for sequestering anthocyanins into the vacuole. [TT19]
      Title: Arabidopsis TT19 functions as a carrier to transport anthocyanin from the cytosol to tonoplasts.
    2. A tt19 allele with a single amino acid substitution caused reduced accumulation of anthocyanidin and proanthocyanidins.
      Title: The Arabidopsis tt19-4 mutant differentially accumulates proanthocyanidin and anthocyanin through a 3' amino acid substitution in glutathione S-transferase.
    3. TT19 functions in the cytosol to maintain the regular accumulation of proanthocyanidin precursors in the vacuole.
      Title: Metabolic profiling and cytological analysis of proanthocyanidins in immature seeds of Arabidopsis thaliana flavonoid accumulation mutants.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_121728.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cation binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anthocyanin-containing compound metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of flavonol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within toxin catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutathione S-transferase phi 12
    NP_197224.1
    • glutathione S-transferase phi 12 (GSTF12); CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Glutathione S-transferase, C-terminal (InterPro:IPR004046), Glutathione S-transferase, C-terminal-like (InterPro:IPR010987), Glutathione S-transferase/chloride channel, C-terminal (InterPro:IPR017933), Glutathione S-transferase, N-terminal (InterPro:IPR004045), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: glutathione S-transferase F11 (TAIR:AT3G03190.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5658416..5659661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121728.4 → NP_197224.1  glutathione S-transferase phi 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197224.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5DWV6, Q9FE46
      UniProtKB/TrEMBL
      A0A178UDJ7, A0A5S9Y5Q4
      Conserved Domains (3) summary
      PLN02473
      Location:1 → 214
      PLN02473; glutathione S-transferase
      cd03187
      Location:91 → 209
      GST_C_Phi; C-terminal, alpha helical domain of Class Phi Glutathione S-transferases
      cd03053
      Location:2 → 77
      GST_N_Phi; GST_N family, Class Phi subfamily; composed of plant-specific class Phi GSTs and related fungal and bacterial proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FE46.1

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