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    GNL1 GNOM-like 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833946, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GNL1
    Official Full Name
    GNOM-like 1
    Primary source
    TAIR:AT5G39500
    Locus tag
    AT5G39500
    See related
    Araport:AT5G39500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ENDOPLASMIC RETICULUM MORPHOLOGY 1; ERMO1; GNOM-like 1; MUL8.180; MUL8_180
    Summary
    Encodes GNOM-LIKE1/ERMO1, a member of ARF-GEF family. Required for endoplasmic reticulum (ER) morphology.
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    Genomic context

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    See GNL1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (15814559..15820151)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Plant self-incompatibility protein S1 family Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene Vesicle transport v-SNARE family protein Neighboring gene hypothetical protein (DUF1997)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The integrity of the plant Golgi apparatus depends on cell growth-controlled activity of GNL1. Du W, et al. Mol Plant, 2013 May. PMID 23125314
    2. An ARF-GEF acting at the Golgi and in selective endocytosis in polarized plant cells. Teh OK, et al. Nature, 2007 Jul 26. PMID 17653191
    3. GNOM-LIKE1/ERMO1 and SEC24a/ERMO2 are required for maintenance of endoplasmic reticulum morphology in Arabidopsis thaliana. Nakano RT, et al. Plant Cell, 2009 Nov. PMID 19933201, Free PMC Article
    4. Functional diversification of closely related ARF-GEFs in protein secretion and recycling. Richter S, et al. Nature, 2007 Jul 26. PMID 17653190
    5. GNOM-LIKE 2, encoding an adenosine diphosphate-ribosylation factor-guanine nucleotide exchange factor protein homologous to GNOM and GNL1, is essential for pollen germination in Arabidopsis. Jia DJ, et al. J Integr Plant Biol, 2009 Aug. PMID 19686373

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data reveal an unanticipated level of complexity in the biology of GNL1 by showing that its cellular roles are correlated with cell growth.
      Title: The integrity of the plant Golgi apparatus depends on cell growth-controlled activity of GNL1.
    2. GNL2 encodes a protein homologous to the adenosine diphosphate-ribosylation factor-guanine nucleotide exchange factors, GNOM and GNL1 that are involved in endosomal recycling and endoplasmic reticulum-Golgi vesicular trafficking
      Title: GNOM-LIKE 2, encoding an adenosine diphosphate-ribosylation factor-guanine nucleotide exchange factor protein homologous to GNOM and GNL1, is essential for pollen germination in Arabidopsis.
    3. GNL1 is a BFA-resistant GBF protein that functions with a BFA-sensitive ARF-GEF both at the Golgi and in selective endocytosis, but not in recycling from endosomes. [GNL1]
      Title: An ARF-GEF acting at the Golgi and in selective endocytosis in polarized plant cells.
    4. Large ARF-GEFs of the GBF1 class perform a conserved role in endoplasmic reticulum-Golgi trafficking and secretion, which is done by GNL1 and GNOM in Arabidopsis. [GNL1]
      Title: Functional diversification of closely related ARF-GEFs in protein secretion and recycling.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001344295.1
    NM_123312.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ER body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GNOM-like 1
    NP_001318705.1
    • GNOM-like 1 (GNL1); FUNCTIONS IN: ARF guanyl-nucleotide exchange factor activity; INVOLVED IN: ER body organization; LOCATED IN: intracellular; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: SEC7-like (InterPro:IPR000904); BEST Arabidopsis thaliana protein match is: sec7 domain-containing protein (TAIR:AT1G13980.2); Has 2885 Blast hits to 2457 proteins in 243 species: Archae - 0; Bacteria - 32; Metazoa - 1491; Fungi - 682; Plants - 262; Viruses - 0; Other Eukaryotes - 418 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      15814559..15820151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001344295.1 → NP_001318705.1  GNOM-like 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FLY5
      UniProtKB/TrEMBL
      A0A178UGI4, A0A5S9Y9Q8, A0A654G6L0
      Conserved Domains (1) summary
      PLN03076
      Location:352 → 1295
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional

    2. NM_123312.2 → NP_198766.1  GNOM-like 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198766.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FLY5
      UniProtKB/TrEMBL
      A0A178UGI4, A0A5S9Y9Q8, A0A654G6L0
      Conserved Domains (1) summary
      PLN03076
      Location:352 → 1295
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FLY5.1

    Gene LinkOut

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