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    BKI1 BRI1 kinase inhibitor 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834284, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BKI1
    Official Full Name
    BRI1 kinase inhibitor 1
    Primary source
    TAIR:AT5G42750
    Locus tag
    AT5G42750
    See related
    Araport:AT5G42750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BRI1 kinase inhibitor 1; MJB21.13; MJB21_13
    Summary
    Encodes a plasma-membrane associated phosphoprotein that interacts directly with the kinase domain of BRI1. It interferes with the interaction between BRI1 with its signalling partner, the plasma membrane localised LRR-receptor kinase BAK1.
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    Genomic context

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    See BKI1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_003076.8 (17142816..17144672, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene Sugar isomerase (SIS) family protein Neighboring gene Leucine carboxyl methyltransferase Neighboring gene ncRNA Neighboring gene plasma membrane fusion protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dual role of BKI1 and 14-3-3 s in brassinosteroid signaling to link receptor with transcription factors. Wang H, et al. Dev Cell, 2011 Nov 15. PMID 22075146
    2. The Arabidopsis U-box E3 ubiquitin ligase PUB30 negatively regulates salt tolerance by facilitating BRI1 kinase inhibitor 1 (BKI1) degradation. Zhang M, et al. Plant Cell Environ, 2017 Nov. PMID 28865087
    3. BKI1 Regulates Plant Architecture through Coordinated Inhibition of the Brassinosteroid and ERECTA Signaling Pathways in Arabidopsis. Wang D, et al. Mol Plant, 2017 Feb 13. PMID 27988365
    4. The Intrinsically Disordered Protein BKI1 Is Essential for Inhibiting BRI1 Signaling in Plants. Jiang J, et al. Mol Plant, 2015 Nov 2. PMID 26296798
    5. Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1. Wang J, et al. Cell Res, 2014 Nov. PMID 25331450, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PUB30 negatively regulates salt tolerance probably through regulating the degradation of BKI1 and brassinosteroids signaling in Arabidopsis.
      Title: The Arabidopsis U-box E3 ubiquitin ligase PUB30 negatively regulates salt tolerance by facilitating BRI1 kinase inhibitor 1 (BKI1) degradation.
    2. BKI1 functions as a common suppressor of the BRI1 and ER signaling pathways
      Title: BKI1 Regulates Plant Architecture through Coordinated Inhibition of the Brassinosteroid and ERECTA Signaling Pathways in Arabidopsis.
    3. BRI1 KINASE INHIBITOR 1 (BKI1) is tyrosine phosphorylated in response to brassinosteroid perception.
      Title: Tyrosine phosphorylation controls brassinosteroid receptor activation by triggering membrane release of its kinase inhibitor.
    4. a BRI1-interacting protein, BKI1, a negative regulator of brassinosteroid signaling is reported; BKI1 is a substrate of BRI1 kinase & limits interaction of BRI1 with its proposed coreceptor, BAK1, suggesting that BKI1 prevents activation of BRI1 [BKI1]
      Title: Brassinosteroids regulate dissociation of BKI1, a negative regulator of BRI1 signaling, from the plasma membrane.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_123639.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of brassinosteroid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BRI1 kinase inhibitor 1
    NP_568610.1
    • BRI1 kinase inhibitor 1 (BKI1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      17142816..17144672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123639.3 → NP_568610.1  BRI1 kinase inhibitor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568610.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LBG8, Q9FMZ0
      UniProtKB/TrEMBL
      A0A178UI38, A0A5S9YAD5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FMZ0.1

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