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    WOX8 WUSCHEL related homeobox 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834638, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WOX8
    Official Full Name
    WUSCHEL related homeobox 8
    Primary source
    TAIR:AT5G45980
    Locus tag
    AT5G45980
    See related
    Araport:AT5G45980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MCL19.2; MCL19_2; STIMPY-LIKE; STPL; WOX9B; WUSCHEL related homeobox 8; WUSCHEL related homeobox 9B
    Summary
    Arabidopsis thaliana WOX8 protein. Contains similarity to homeodomain transcription factor. Positively regulates early embryonic growth. Together with CLE8 it forms a signaling module that promotes seed growth and overall seed size.
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    Genomic context

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    See WOX8 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (18648886..18650836)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene RAC-like 2 Neighboring gene crooked neck protein, putative / cell cycle protein Neighboring gene Mannose-binding lectin superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. WOX2 and STIMPY-LIKE/WOX8 promote cotyledon boundary formation in Arabidopsis. Lie C, et al. Plant J, 2012 Nov. PMID 22827849
    2. Regulation of Arabidopsis embryo and endosperm development by the polypeptide signaling molecule CLE8. Fiume E, et al. Plant Cell, 2012 Mar. PMID 22427333, Free PMC Article
    3. The RWP-RK factor GROUNDED promotes embryonic polarity by facilitating YODA MAP kinase signaling. Jeong S, et al. Curr Biol, 2011 Aug 9. PMID 21802295
    4. Transcriptional activation of Arabidopsis axis patterning genes WOX8/9 links zygote polarity to embryo development. Ueda M, et al. Dev Cell, 2011 Feb 15. PMID 21316593
    5. Differential expression of WOX genes mediates apical-basal axis formation in the Arabidopsis embryo. Breuninger H, et al. Dev Cell, 2008 Jun. PMID 18539115

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of WOX2 and WOX8 lead to the development of partially fused cotyledons.
      Title: WOX2 and STIMPY-LIKE/WOX8 promote cotyledon boundary formation in Arabidopsis.
    2. CLE8 positively regulates expression of the WUS-related gene WOX8.
      Title: Regulation of Arabidopsis embryo and endosperm development by the polypeptide signaling molecule CLE8.
    3. Expression of WOX8 is independent of the axis patterning signal auxin, but, together with the redundant gene WOX9, is activated in the zygote, its basal daughter cell, and the hypophysis by the zinc-finger transcription factor WRKY2.
      Title: Transcriptional activation of Arabidopsis axis patterning genes WOX8/9 links zygote polarity to embryo development.
    4. Differential expression of WOX8 gene mediates apical-basal axis formation in the Arabidopsis embryo.
      Title: Differential expression of WOX genes mediates apical-basal axis formation in the Arabidopsis embryo.
    5. combinatorial action of WOX transcription factors is essential for Arabidopsis embryonic development.
      Title: Combinations of WOX activities regulate tissue proliferation during Arabidopsis embryonic development.
    Submit: New GeneRIF Correction

    General gene information

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    NM_123966.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cotyledon boundary formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cotyledon development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cotyledon development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of developmental process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    WUSCHEL related homeobox 8
    NP_199410.2
    • WUSCHEL related homeobox 8 (WOX8); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057); BEST Arabidopsis thaliana protein match is: homeobox-3 (TAIR:AT2G33880.1); Has 568 Blast hits to 538 proteins in 48 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 568; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18648886..18650836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123966.3 → NP_199410.2  WUSCHEL related homeobox 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199410.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6X7J5, Q9FNM4
      UniProtKB/TrEMBL
      A0A178UI57, A0A5S9YBQ7
      Conserved Domains (1) summary
      pfam00046
      Location:54 → 114
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6X7J5.1

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