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    PPOX pyridoxin (pyrodoxamine) 5'-phosphate oxidase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835061, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PPOX
    Official Full Name
    pyridoxin (pyrodoxamine) 5'-phosphate oxidase
    Primary source
    TAIR:AT5G49970
    Locus tag
    AT5G49970
    See related
    Araport:AT5G49970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPPOX; HOMOLOG OF YEAST PYRIDOXINE AUXOTROPHY 3; K9P8.11; K9P8_11; PDX3; pyridoxin (pyrodoxamine) 5'-phosphate oxidase
    Summary
    encodes the bifunctional pyridoxine (pyridoxamine) 5#Aeo-phosphate oxidase (PPOX)(EC 1.4.3.5) that is involved in the formation of pyridoxal 5'-phosphate (member of the vitamin B6 group)
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    Genomic context

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    See PPOX in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (20329103..20333172)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene hypothetical protein (DUF1682) Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ion channel protein Neighboring gene auxin F-box protein 5 Neighboring gene Xanthine/uracil permease family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PYRIDOX(AM)INE 5'-PHOSPHATE OXIDASE3 of Arabidopsis thaliana maintains carbon/nitrogen balance in distinct environmental conditions. Steensma P, et al. Plant Physiol, 2023 Sep 22. PMID 37453131, Free PMC Article
    2. Expression, in vivo localization and phylogenetic analysis of a pyridoxine 5'-phosphate oxidase in Arabidopsis thaliana. Sang Y, et al. Plant Physiol Biochem, 2011 Jan. PMID 21051239
    3. Plants utilize a highly conserved system for repair of NADH and NADPH hydrates. Niehaus TD, et al. Plant Physiol, 2014 May. PMID 24599492, Free PMC Article
    4. Vitamer levels, stress response, enzyme activity, and gene regulation of Arabidopsis lines mutant in the pyridoxine/pyridoxamine 5'-phosphate oxidase (PDX3) and the pyridoxal kinase (SOS4) genes involved in the vitamin B6 salvage pathway. González E, et al. Plant Physiol, 2007 Nov. PMID 17873088, Free PMC Article
    5. Identification of a pyridoxine (pyridoxamine) 5'-phosphate oxidase from Arabidopsis thaliana. Sang Y, et al. FEBS Lett, 2007 Feb 6. PMID 17224143

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PYRIDOX(AM)INE 5'-PHOSPHATE OXIDASE3 of Arabidopsis thaliana maintains carbon/nitrogen balance in distinct environmental conditions.
      Title: PYRIDOX(AM)INE 5'-PHOSPHATE OXIDASE3 of Arabidopsis thaliana maintains carbon/nitrogen balance in distinct environmental conditions.
    2. The phenotype, stress responses, vitamer levels, and regulation of the vitamin B6 pathway genes in Arabidopsis plants mutant in pyridoxine/pyridoxamine 5'-phosphate oxidase (PDX3) and SALT OVERLY SENSITIVE4 (SOS4) are reported.[PDX3]
      Title: Vitamer levels, stress response, enzyme activity, and gene regulation of Arabidopsis lines mutant in the pyridoxine/pyridoxamine 5'-phosphate oxidase (PDX3) and the pyridoxal kinase (SOS4) genes involved in the vitamin B6 salvage pathway.
    3. cDNA corresponding to putative PPOX was obtained
      Title: Identification of a pyridoxine (pyridoxamine) 5'-phosphate oxidase from Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_124376.4
    NM_203189.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD(P)HX epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxamine phosphate oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within NADH metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within NADP metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pyridoxal metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    pyridoxin (pyrodoxamine) 5'-phosphate oxidase
    NP_568717.2
    • pyridoxin (pyrodoxamine) 5'-phosphate oxidase (PPOX); CONTAINS InterPro DOMAIN/s: YjeF-related protein, N-terminal (InterPro:IPR004443), FMN-binding split barrel (InterPro:IPR012349), Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain (InterPro:IPR011576), FMN-binding split barrel, related (InterPro:IPR009002), Pyridoxamine 5'-phosphate oxidase, rossman domain-containing, predicted, plant (InterPro:IPR021198), Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal (InterPro:IPR019576), Pyridoxamine 5'-phosphate oxidase (InterPro:IPR000659), Pyridoxamine 5'-phosphate oxidase, conserved site (InterPro:IPR019740); Has 8784 Blast hits to 8784 proteins in 2051 species: Archae - 190; Bacteria - 5236; Metazoa - 351; Fungi - 311; Plants - 42; Viruses - 0; Other Eukaryotes - 2654 (source: NCBI BLink).
    NP_974918.1
    • pyridoxin (pyrodoxamine) 5'-phosphate oxidase (PPOX); CONTAINS InterPro DOMAIN/s: Pyridoxamine 5'-phosphate oxidase, rossman domain-containing, predicted, plant (InterPro:IPR021198), YjeF-related protein, N-terminal (InterPro:IPR004443), FMN-binding split barrel (InterPro:IPR012349), Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain (InterPro:IPR011576), FMN-binding split barrel, related (InterPro:IPR009002); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      20329103..20333172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124376.4 → NP_568717.2  pyridoxin (pyrodoxamine) 5'-phosphate oxidase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568717.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4K7H2, Q8L7T7, Q8L9L3, Q9LTX3
      UniProtKB/TrEMBL
      A0A178UP64, A0A5S9YCP3
      Conserved Domains (1) summary
      PLN02918
      Location:4 → 530
      PLN02918; pyridoxine (pyridoxamine) 5'-phosphate oxidase

    2. NM_203189.2 → NP_974918.1  pyridoxin (pyrodoxamine) 5'-phosphate oxidase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974918.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UP64, A0A5S9YCP3
      Conserved Domains (3) summary
      PLN02918
      Location:4 → 466
      PLN02918; pyridoxine (pyridoxamine) 5'-phosphate oxidase
      pfam01243
      Location:336 → 421
      Pyridox_oxidase; Pyridoxamine 5'-phosphate oxidase
      cl00318
      Location:65 → 298
      YjeF_N; YjeF-related protein N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LTX3.1

    Gene LinkOut

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