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    ABI2 Protein phosphatase 2C family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835809, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ABI2
    Official Full Name
    Protein phosphatase 2C family protein
    Primary source
    TAIR:AT5G57050
    Locus tag
    AT5G57050
    See related
    Araport:AT5G57050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ABA INSENSITIVE 2; AtABI2; MHM17.19; MHM17_19; PROTEIN PHOSPHATASE 2C
    Summary
    Encodes a protein phosphatase 2C and is involved in ABA signal transduction. Binds fibrillin preprotein in vitro and in vivo.
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    Genomic context

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    See ABI2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (23087122..23089631)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene myristoyl-CoA:protein N-myristoyltransferase Neighboring gene Lycopene beta/epsilon cyclase protein Neighboring gene U-box domain-containing protein kinase family protein Neighboring gene Lactoylglutathione lyase / glyoxalase I family protein Neighboring gene 60S ribosomal L18a-like protein Neighboring gene hydroxyproline-rich glycoprotein family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ABA INSENSITIVE 2 promotes flowering by inhibiting OST1/ABI5-dependent FLOWERING LOCUS C transcription in Arabidopsis. Ali A, et al. J Exp Bot, 2024 Apr 15. PMID 38280208, Free PMC Article
    2. The Arabidopsis ABSCISIC ACID-INSENSITIVE2 (ABI2) and ABI1 genes encode homologous protein phosphatases 2C involved in abscisic acid signal transduction. Leung J, et al. Plant Cell, 1997 May. PMID 9165752, Free PMC Article
    3. ABI2, a second protein phosphatase 2C involved in abscisic acid signal transduction in Arabidopsis. Rodriguez PL, et al. FEBS Lett, 1998 Jan 16. PMID 9468303
    4. The ABI1 and ABI2 protein phosphatases 2C act in a negative feedback regulatory loop of the abscisic acid signalling pathway. Merlot S, et al. Plant J, 2001 Feb. PMID 11208021
    5. The ABI2-dependent abscisic acid signalling controls HrpN-induced drought tolerance in Arabidopsis. Dong HP, et al. Planta, 2005 Jun. PMID 15599761

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ABA INSENSITIVE 2 promotes flowering by inhibiting OST1/ABI5-dependent FLOWERING LOCUS C transcription in Arabidopsis.
      Title: ABA INSENSITIVE 2 promotes flowering by inhibiting OST1/ABI5-dependent FLOWERING LOCUS C transcription in Arabidopsis.
    2. TMK1-based auxin signaling regulates abscisic acid responses via phosphorylating ABI1/2 in Arabidopsis.
      Title: TMK1-based auxin signaling regulates abscisic acid responses via phosphorylating ABI1/2 in Arabidopsis.
    3. ABI1, ABI2, and HAI1 promoters of PP2C are regulated by repressors; BRM ATPase contributes to the repression of PP2C gene transcription
      Title: Chromatin remodeling for the transcription of type 2C protein phosphatase genes in response to salt stress.
    4. The role of ABI2 in the activation of nuclear genes during transcription of chloroplast genes
      Title: Abscisic acid affects transcription of chloroplast genes via protein phosphatase 2C-dependent activation of nuclear genes: repression by guanosine-3'-5'-bisdiphosphate and activation by sigma factor 5.
    5. findings suggest that ABI2 may functionally link stress-regulated control of growth and nitrate uptake and utilization, which are energy-expensive processes.
      Title: Nitrate sensing and uptake in Arabidopsis are enhanced by ABI2, a phosphatase inactivated by the stress hormone abscisic acid.
    6. Data indicate that PYL8 interacted in vivo with at least five PP2Cs, namely HAB1, HAB2, ABI1, ABI2, and PP2CA.
      Title: PYRABACTIN RESISTANCE1-LIKE8 plays an important role for the regulation of abscisic acid signaling in root.
    7. Two dominant-negative mutations in ABA insensitive1 (abi1-1) and abi2-1 greatly reduced ROS production in mitochondria.
      Title: DEXH box RNA helicase-mediated mitochondrial reactive oxygen species production in Arabidopsis mediates crosstalk between abscisic acid and auxin signaling.
    8. AtOZF2 is involved in the abscissic acid and salt stress response through the ABI2-mediated signaling pathway.
      Title: Molecular and physiological characterization of the Arabidopsis thaliana Oxidation-related Zinc Finger 2, a plasma membrane protein involved in ABA and salt stress response through the ABI2-mediated signaling pathway.
    9. Data reveal that this CPL is an important site necessary for both the phosphatase activity of ABI2 and the functional interaction between ABI2 and PYL5/9 ABA receptors.
      Title: Identification of an important site for function of the type 2C protein phosphatase ABI2 in abscisic acid signalling in Arabidopsis.
    10. study reports a SnRK2-PP2C complex structure, which reveals marked similarity in PP2C recognition by SnRK2 and ABA receptors; structural results provide a simple mechanism that directly couples ABA binding to SnRK2 kinase activation
      Title: Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001125976.2
    NM_001345230.1
    NM_125087.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of abscisic acid-activated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within photoinhibition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein dephosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal opening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    part_of protein serine/threonine phosphatase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein phosphatase 2C family protein
    NP_001119448.1
    • ABA INSENSITIVE 2 (ABI2); CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C, manganese/magnesium aspartate binding site (InterPro:IPR000222), Protein phosphatase 2C-related (InterPro:IPR001932), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045); BEST Arabidopsis thaliana protein match is: Protein phosphatase 2C family protein (TAIR:AT4G26080.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_200515.1
    • ABA INSENSITIVE 2 (ABI2); CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C, manganese/magnesium aspartate binding site (InterPro:IPR000222), Protein phosphatase 2C-related (InterPro:IPR001932), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045); BEST Arabidopsis thaliana protein match is: Protein phosphatase 2C family protein (TAIR:AT4G26080.1); Has 6785 Blast hits to 6667 proteins in 423 species: Archae - 6; Bacteria - 246; Metazoa - 1749; Fungi - 768; Plants - 2698; Viruses - 7; Other Eukaryotes - 1311 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23087122..23089631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125087.3 → NP_200515.1  Protein phosphatase 2C family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200515.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H561, O04719
      UniProtKB/TrEMBL
      A0A178UGB7, A0A5S9YES7
      Conserved Domains (1) summary
      smart00332
      Location:103 → 409
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

    2. NM_001345230.1 → NP_001331640.1  Protein phosphatase 2C family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BEK2
      Conserved Domains (1) summary
      smart00332
      Location:103 → 308
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

    3. NM_001125976.2 → NP_001119448.1  Protein phosphatase 2C family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119448.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2FGV8
      Conserved Domains (1) summary
      smart00332
      Location:63 → 369
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04719.1

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