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    MBD6 methyl-CPG-binding domain 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836057, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MBD6
    Official Full Name
    methyl-CPG-binding domain 6
    Primary source
    TAIR:AT5G59380
    Locus tag
    AT5G59380
    See related
    Araport:AT5G59380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMBD6; F2O15.4; F2O15_4; methyl-CPG-binding domain 6
    Summary
    Protein containing methyl-CpG-binding domain.Has sequence similarity to human MBD proteins.
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    Genomic context

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    See MBD6 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (23952132..23953707)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene actin 4 Neighboring gene tRNA-Gly Neighboring gene XH/XS domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multimegabase silencing in nucleolar dominance involves siRNA-directed DNA methylation and specific methylcytosine-binding proteins. Preuss SB, et al. Mol Cell, 2008 Dec 5. PMID 19061642, Free PMC Article
    2. Arabidopsis MBD proteins show different binding specificities and nuclear localization. Scebba F, et al. Plant Mol Biol, 2003 Nov. PMID 15010609
    3. The three methyl-CpG-binding domains of AtMBD7 control its subnuclear localization and mobility. Zemach A, et al. J Biol Chem, 2008 Mar 28. PMID 18211904, Free PMC Article
    4. DDM1 binds Arabidopsis methyl-CpG binding domain proteins and affects their subnuclear localization. Zemach A, et al. Plant Cell, 2005 May. PMID 15805479, Free PMC Article
    5. AtMBD6, a methyl CpG binding domain protein, maintains gene silencing in Arabidopsis by interacting with RNA binding proteins. Parida AP, et al. J Biosci, 2017 Mar. PMID 28229965

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_125329.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables cytosine C-5 DNA demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables methyl-CpG binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyl-CpG binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus organizer region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in perinucleolar chromocenter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    methyl-CPG-binding domain 6
    NP_200746.1
    • methyl-CPG-binding domain 6 (MBD6); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Methyl-CpG DNA binding (InterPro:IPR001739); BEST Arabidopsis thaliana protein match is: methyl-CPG-binding domain protein 5 (TAIR:AT3G46580.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23952132..23953707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125329.4 → NP_200746.1  methyl-CPG-binding domain 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200746.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LTJ1
      UniProtKB/TrEMBL
      A0A178UI30, A0A5S9YFF5
      Conserved Domains (1) summary
      cd01396
      Location:75 → 155
      MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LTJ1.1

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