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    MUM2 Glycosyl hydrolase family 35 protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836500, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MUM2
    Official Full Name
    Glycosyl hydrolase family 35 protein
    Primary source
    TAIR:AT5G63800
    Locus tag
    AT5G63800
    See related
    Araport:AT5G63800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    beta-galactosidase 6; BGAL6; MBK5.28; MBK5_28; MUCILAGE-MODIFIED 2
    Summary
    Involved in mucilage formation. Mutants form columella and outer cell wall architecture of the mucilage cells resembles wild-type. However, mum2 seeds completely lack seed coat mucilage. This mutation appears to represent a later step in the development of this cell-type. Encodes a beta-galactosidase involved in seed coat mucilage biosynthesis. Member of Glycoside Hydrolase Family 35
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    Genomic context

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    See MUM2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Sequence:
    Chromosome: 5; NC_003076.8 (25530055..25535889)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase 2 Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene NAC domain containing protein 102 Neighboring gene miscRNA Neighboring gene beta-galactosidase 10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A naturally occurring mutation in an Arabidopsis accession affects a beta-D-galactosidase that increases the hydrophilic potential of rhamnogalacturonan I in seed mucilage. Macquet A, et al. Plant Cell, 2007 Dec. PMID 18165330, Free PMC Article
    2. The Arabidopsis MUM2 gene encodes a beta-galactosidase required for the production of seed coat mucilage with correct hydration properties. Dean GH, et al. Plant Cell, 2007 Dec. PMID 18165329, Free PMC Article
    3. The transcriptional regulator LEUNIG_HOMOLOG regulates mucilage release from the Arabidopsis testa. Walker M, et al. Plant Physiol, 2011 May. PMID 21402796, Free PMC Article
    4. The Arabidopsis transcription factor LUH/MUM1 is required for extrusion of seed coat mucilage. Huang J, et al. Plant Physiol, 2011 Jun. PMID 21518777, Free PMC Article
    5. Isolation and characterization of mutants defective in seed coat mucilage secretory cell development in Arabidopsis. Western TL, et al. Plant Physiol, 2001 Nov. PMID 11706181, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LUH is allelic to MUM1, and MUM2 is a likely target of LUH regulation. The transcriptional corepressor LEUNIG (LUG) is functionally interchangeable with LUH, raising the possibility that LUH functions as a repressor during seed coat maturation.
      Title: The transcriptional regulator LEUNIG_HOMOLOG regulates mucilage release from the Arabidopsis testa.
    2. Data conclude that the MUM2/BGAL6 beta-D-galactosidase is required for maturation of rhamnogalacturonan I in seed mucilage by the removal of galactose/galactan branches, resulting in increased swelling and extrusion of the mucilage on seed hydration.
      Title: A naturally occurring mutation in an Arabidopsis accession affects a beta-D-galactosidase that increases the hydrophilic potential of rhamnogalacturonan I in seed mucilage.
    3. Results show MUM2 is localized to the cell wall and it is proposed that MUM2 is involved in modifying mucilage to allow it to expand upon hydration, establishing a link between the galactosyl side-chain structure of pectin and its physical properties.
      Title: The Arabidopsis MUM2 gene encodes a beta-galactosidase required for the production of seed coat mucilage with correct hydration properties.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_125775.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables beta-galactosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mucilage biosynthetic process involved in seed coat development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type cell wall modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type cell wall HDA PubMed 
    located_in plant-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    Glycosyl hydrolase family 35 protein
    NP_568978.2
    • MUCILAGE-MODIFIED 2 (MUM2); FUNCTIONS IN: beta-galactosidase activity; INVOLVED IN: plant-type cell wall modification, mucilage biosynthetic process involved in seed coat development; LOCATED IN: apoplast, cell wall; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glycoside hydrolase, family 35, conserved site (InterPro:IPR019801), Glycoside hydrolase, family 35 (InterPro:IPR001944), Glycoside hydrolase, catalytic core (InterPro:IPR017853), Glycoside hydrolase, subgroup, catalytic core (InterPro:IPR013781), Galactose-binding domain-like (InterPro:IPR008979); BEST Arabidopsis thaliana protein match is: beta-galactosidase 16 (TAIR:AT1G77410.1); Has 2471 Blast hits to 2080 proteins in 478 species: Archae - 15; Bacteria - 1165; Metazoa - 401; Fungi - 216; Plants - 595; Viruses - 0; Other Eukaryotes - 79 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25530055..25535889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125775.4 → NP_568978.2  Glycosyl hydrolase family 35 protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568978.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WMN2, Q9FFN4, Q9SCV6
      UniProtKB/TrEMBL
      A0A178URV0, A0A5S9YIY1
      Conserved Domains (1) summary
      PLN03059
      Location:10 → 702
      PLN03059; beta-galactosidase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FFN4.1

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