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    MBD02 methyl-CPG-binding domain protein 02 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833487, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MBD02
    Official Full Name
    methyl-CPG-binding domain protein 02
    Primary source
    TAIR:AT5G35330
    Locus tag
    AT5G35330
    See related
    Araport:AT5G35330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMBD2; MBD2; methyl-CPG-binding domain protein 02; METHYL-CPG-BINDING DOMAIN PROTEIN 2; T26D22.18; T26D22_18
    Summary
    Protein containing methyl-CpG-binding domain.Has sequence similarity to human MBD proteins.
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    Genomic context

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    See MBD02 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (13523403..13525834, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene DBH-like monooxygenase Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DDM1 binds Arabidopsis methyl-CpG binding domain proteins and affects their subnuclear localization. Zemach A, et al. Plant Cell, 2005 May. PMID 15805479, Free PMC Article
    2. Methylated DNA-binding proteins from Arabidopsis. Ito M, et al. Plant Physiol, 2003 Dec. PMID 14605234, Free PMC Article
    3. Characterization of Arabidopsis thaliana methyl-CpG-binding domain (MBD) proteins. Zemach A, et al. Plant J, 2003 Jun. PMID 12787239
    4. Arabidopsis RPD3-like histone deacetylases form multiple complexes involved in stress response. Feng C, et al. J Genet Genomics, 2021 May 20. PMID 34144927
    5. CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. Wanamaker SA, et al. Nat Methods, 2017 Aug. PMID 28650476, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203492.2
    NM_001344102.1
    NM_122924.3
    NM_203121.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables cytosine C-5 DNA demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of NuRD complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    methyl-CPG-binding domain protein 02
    NP_001190421.1
    • methyl-CPG-binding domain protein 02 (MBD02); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Methyl-CpG DNA binding (InterPro:IPR001739), Zinc finger, CW-type (InterPro:IPR011124); BEST Arabidopsis thaliana protein match is: methyl-CPG-binding domain 12 (TAIR:AT5G35338.2).
    NP_198383.1
    • methyl-CPG-binding domain protein 02 (MBD02); FUNCTIONS IN: DNA binding; INVOLVED IN: biological_process unknown; LOCATED IN: nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Methyl-CpG DNA binding (InterPro:IPR001739), Zinc finger, CW-type (InterPro:IPR011124); BEST Arabidopsis thaliana protein match is: methyl-CPG-binding domain 12 (TAIR:AT5G35338.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_974850.1
    • methyl-CPG-binding domain protein 02 (MBD02); FUNCTIONS IN: DNA binding; INVOLVED IN: biological_process unknown; LOCATED IN: nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Methyl-CpG DNA binding (InterPro:IPR001739), Zinc finger, CW-type (InterPro:IPR011124); BEST Arabidopsis thaliana protein match is: methyl-CPG-binding domain 12 (TAIR:AT5G35338.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      13523403..13525834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203492.2 → NP_001190421.1  methyl-CPG-binding domain protein 02 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190421.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65234, Q0WRD3, Q84TJ8, Q8LA53, Q9FZP7
      UniProtKB/TrEMBL
      A0A178U6X6
      Conserved Domains (2) summary
      cd01396
      Location:122 → 201
      MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
      pfam07496
      Location:59 → 110
      zf-CW; CW-type Zinc Finger

    2. NM_122924.3 → NP_198383.1  methyl-CPG-binding domain protein 02 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198383.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65234, Q0WRD3, Q84TJ8, Q8LA53, Q9FZP7
      UniProtKB/TrEMBL
      A0A178U6X6
      Conserved Domains (2) summary
      cd01396
      Location:122 → 201
      MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
      pfam07496
      Location:59 → 110
      zf-CW; CW-type Zinc Finger

    3. NM_203121.3 → NP_974850.1  methyl-CPG-binding domain protein 02 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974850.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65234, Q0WRD3, Q84TJ8, Q8LA53, Q9FZP7
      UniProtKB/TrEMBL
      A0A178U6X6
      Conserved Domains (2) summary
      cd01396
      Location:122 → 201
      MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
      pfam07496
      Location:59 → 110
      zf-CW; CW-type Zinc Finger

    4. NM_001344102.1 → NP_001331130.1  methyl-CPG-binding domain protein 02 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65234, Q0WRD3, Q84TJ8, Q8LA53, Q9FZP7
      UniProtKB/TrEMBL
      A0A178U6X6
      Conserved Domains (2) summary
      cd01396
      Location:122 → 201
      MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
      pfam07496
      Location:59 → 110
      zf-CW; CW-type Zinc Finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LA53.1

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