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    S1P SITE-1 protease [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832086, updated on 18-Sep-2024

    Summary

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    Official Symbol
    S1P
    Official Full Name
    SITE-1 protease
    Primary source
    TAIR:AT5G19660
    Locus tag
    AT5G19660
    See related
    Araport:AT5G19660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATS1P; ATSBT6.1; SITE-1 protease; SITE-1 PROTEASE; T29J13.80; T29J13_80
    Summary
    S1P appears to function as a Golgi-localized subtilase and to help protect seedlings against salt and osmotic stress. The roots of s1p-3 mutants are hypersensitive to NaCl, KCl, LiCl, and mannitol. Several salt-stress responsive genes show weaker induction in an s1P-3 mutant background. The proteolytic cleavage of the bZIP17 transcription factor depends on S1P in vitro. And there is evidence that S1P can cleave bZIP17 in vitro.
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    Genomic context

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    See S1P in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (6641907..6646550, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily protein Neighboring gene ovate family protein 8 Neighboring gene Exostosin family protein Neighboring gene uncharacterized protein Neighboring gene Leucine-rich repeat (LRR) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Salt stress responses in Arabidopsis utilize a signal transduction pathway related to endoplasmic reticulum stress signaling. Liu JX, et al. Plant J, 2007 Sep. PMID 17662035, Free PMC Article
    2. The SBT6.1 subtilase processes the GOLVEN1 peptide controlling cell elongation. Ghorbani S, et al. J Exp Bot, 2016 Aug. PMID 27315833, Free PMC Article
    3. The N-terminal pro region mediates retention of unprocessed type-I PME in the Golgi apparatus. Wolf S, et al. Plant J, 2009 May. PMID 19144003
    4. Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Parsons HT, et al. Plant Physiol, 2012 May. PMID 22430844, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001343619.1
    NM_001343620.1
    NM_121971.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hyperosmotic salinity response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    SITE-1 protease
    NP_197467.1
    • SITE-1 protease (S1P); CONTAINS InterPro DOMAIN/s: Peptidase S8/S53, subtilisin/kexin/sedolisin (InterPro:IPR000209), Peptidase S8, subtilisin-related (InterPro:IPR015500), Peptidase S8/S53, subtilisin, active site (InterPro:IPR022398); BEST Arabidopsis thaliana protein match is: Subtilisin-like serine endopeptidase family protein (TAIR:AT1G20160.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      6641907..6646550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121971.3 → NP_197467.1  SITE-1 protease [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197467.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WUG6, Q8L7B7
      UniProtKB/TrEMBL
      A0A178UNR0, A0A5S9Y5X5
      Conserved Domains (1) summary
      cd07479
      Location:197 → 453
      Peptidases_S8_SKI-1_like; Peptidase S8 family domain in SKI-1-like proteins

    2. NM_001343620.1 → NP_001331147.1  SITE-1 protease [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BD04

    3. NM_001343619.1 → NP_001331146.1  SITE-1 protease [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BD04
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WUG6.1

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