Tuba1c tubulin, alpha 1C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tuba1cprovided by MGI
Official Full Name: tubulin, alpha 1Cprovided by MGI
Primary source: MGI:MGI:1095409
See related: Ensembl:ENSMUSG00000043091 AllianceGenome:MGI:1095409
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: M[a]6; Tuba6
Summary: Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in cytoplasmic microtubule. Is expressed in cerebral cortex. Orthologous to human TUBA1C (tubulin alpha 1c). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 1657.2), CNS E18 (RPKM 1419.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 55.61 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (98927772..98935986)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (99029891..99038105)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC104164P1 (e-PCR)
- UniSTS:270103

D22S1042 (e-PCR)
- UniSTS:67652

X59840 (e-PCR)
- UniSTS:180828

D5Arb10 (e-PCR)
- UniSTS:240478

RH78682 (e-PCR)
- UniSTS:80224

Prph1 (e-PCR), detects polymorphism
- UniSTS:144268

PMC86714P2 (e-PCR)
- UniSTS:273550

Tuba1a (e-PCR), detects polymorphism
- UniSTS:532393

D15Mit42 (e-PCR), detects polymorphism
- UniSTS:127660

RH94483 (e-PCR)
- UniSTS:119731

Prph (e-PCR), detects polymorphism
- UniSTS:265678

PMC154451P2 (e-PCR)
- UniSTS:271312

AI060036 (e-PCR)
- UniSTS:248813

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tubulin alpha-1C chain

Names: alpha-tubulin 6; alpha-tubulin isotype M-alpha-6; tubulin alpha-6 chain; tubulin, alpha 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.