Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bpnt1provided by MGI
Official Full Name: 3'(2'), 5'-bisphosphate nucleotidase 1provided by MGI
Primary source: MGI:MGI:1338800
See related: Ensembl:ENSMUSG00000026617 AllianceGenome:MGI:1338800
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BPntase
Summary: Enables 3'(2'),5'-bisphosphate nucleotidase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Is expressed in apical ectodermal ridge and limb. Orthologous to human BPNT1 (3'(2'), 5'-bisphosphate nucleotidase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in duodenum adult (RPKM 27.7), kidney adult (RPKM 26.7) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H5; 1 89.49 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (185061619..185089974)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (185329428..185357777)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice.
Title: Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice.
These studies define a genetic basis for iron-deficiency anemia, a molecular approach for rescuing loss of nucleotidase function, and an unanticipated link between nucleotide hydrolysis in the sulfur assimilation pathway and iron homeostasis.
Title: Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

D0Nds34 (e-PCR), detects polymorphism
- UniSTS:141462

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'(2'),5'-bisphosphate nucleotidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'(2'),5'-bisphosphate nucleotidase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3'(2'),5'-bisphosphate nucleotidase activity	ISO Inferred from Sequence Orthology more info
enables inositol-1,4-bisphosphate 1-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,4-bisphosphate 1-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 3'(2'),5'-bisphosphate nucleotidase 1

Names: 3'-phosphoadenosine 5'-phosphate phosphatase; BPntase 1; PAP phosphatase; PAP-inositol 1,4-phosphatase; PIP; bisphosphate 3'-nucleotidase 1; inositol-polyphosphate 1-phosphatase

NP_001334139.1

EC 3.1.3.57

EC 3.1.3.7

NP_001334141.1

EC 3.1.3.57

EC 3.1.3.7

NP_035924.2

EC 3.1.3.57

EC 3.1.3.7

XP_006497223.1

EC 3.1.3.57

EC 3.1.3.7

XP_006497224.1

EC 3.1.3.57

EC 3.1.3.7

XP_030109781.1

EC 3.1.3.57

EC 3.1.3.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347210.1 → NP_001334139.1 3'(2'),5'-bisphosphate nucleotidase 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC129195

Consensus CDS

CCDS83657.1

UniProtKB/TrEMBL

A0A1B0GRV0, Q3UBN8

Related

ENSMUSP00000147674.2, ENSMUST00000210277.2

Conserved Domains (1) summary

cd01640
Location:11 → 311

IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
NM_001347212.1 → NP_001334141.1 3'(2'),5'-bisphosphate nucleotidase 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC129195

Consensus CDS

CCDS83658.1

UniProtKB/TrEMBL

D3Z0E6, Q3UBN8

Related

ENSMUSP00000106590.2, ENSMUST00000110965.2
NM_011794.3 → NP_035924.2 3'(2'),5'-bisphosphate nucleotidase 1 isoform 1

See identical proteins and their annotated locations for NP_035924.2

Status: VALIDATED

Source sequence(s)

AC129195

Consensus CDS

CCDS15597.1

UniProtKB/Swiss-Prot

Q3U8Z5, Q91XB9, Q9D7Y0, Q9Z0S1

UniProtKB/TrEMBL

Q3UBN8

Related

ENSMUSP00000027916.7, ENSMUST00000027916.13

Conserved Domains (1) summary

cd01640
Location:11 → 296

IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

185061619..185089974

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497160.5 → XP_006497223.1 3'(2'),5'-bisphosphate nucleotidase 1 isoform X1

See identical proteins and their annotated locations for XP_006497223.1

UniProtKB/TrEMBL

A0A1B0GRV0, Q3UBN8

Conserved Domains (1) summary

cd01640
Location:11 → 311

IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
XM_030253921.2 → XP_030109781.1 3'(2'),5'-bisphosphate nucleotidase 1 isoform X2

UniProtKB/Swiss-Prot

Q3U8Z5, Q91XB9, Q9D7Y0, Q9Z0S1

UniProtKB/TrEMBL

Q3UBN8

Conserved Domains (1) summary

cd01640
Location:11 → 296

IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
XM_006497161.5 → XP_006497224.1 3'(2'),5'-bisphosphate nucleotidase 1 isoform X3

UniProtKB/TrEMBL

Q3UBN8

Conserved Domains (1) summary

cd01640
Location:1 → 256

IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...