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    Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 69568, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Vkorc1l1provided by MGI
    Official Full Name
    vitamin K epoxide reductase complex, subunit 1-like 1provided by MGI
    Primary source
    MGI:MGI:1916818
    See related
    Ensembl:ENSMUSG00000066735 AllianceGenome:MGI:1916818
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310024K08Rik
    Summary
    Enables vitamin-K-epoxide reductase (warfarin-sensitive) activity. Involved in vitamin K metabolic process. Is active in endoplasmic reticulum membrane. Is expressed in liver. Orthologous to human VKORC1L1 (vitamin K epoxide reductase complex subunit 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 7.6), CNS E18 (RPKM 7.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vkorc1l1 in Genome Data Viewer
    Location:
    5 G1.3; 5 68.26 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129970950..130015533)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129942109..129986692)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2766 Neighboring gene zinc finger BED-type containing 5 Neighboring gene STARR-seq mESC enhancer starr_14464 Neighboring gene nuclear protein transcriptional regulator 2 Neighboring gene STARR-positive B cell enhancer ABC_E1308 Neighboring gene STARR-seq mESC enhancer starr_14467 Neighboring gene STARR-seq mESC enhancer starr_14468 Neighboring gene glucuronidase, beta Neighboring gene STARR-positive B cell enhancer ABC_E10355 Neighboring gene argininosuccinate lyase Neighboring gene predicted gene, 40334

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism. Yang X, et al. Cell Metab, 2023 Aug 8. PMID 37467745, Free PMC Article
    2. The Vitamin K Epoxide Reductase Vkorc1l1 Promotes Preadipocyte Differentiation in Mice. Ding Y, et al. Obesity (Silver Spring), 2018 Aug. PMID 29963761
    3. Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain. Caspers M, et al. Thromb Res, 2015 May. PMID 25747820
    4. Vitamin K-dependent carboxylation regulates Ca(2+) flux and adaptation to metabolic stress in β cells. Lacombe J, et al. Cell Rep, 2023 May 30. PMID 37171959, Free PMC Article
    5. GGCX and VKORC1 inhibit osteocalcin endocrine functions. Ferron M, et al. J Cell Biol, 2015 Mar 16. PMID 25753038, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism.
      Title: Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism.
    2. VKORC1L1 supports vitamin K-dependent (VKD) protein protein carboxylation in vivo.
      Title: VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo.
    3. Vkorc1l1 promotes adipogenesis and possibly obesity. Downregulation of Vkorc1l1 increases intracellular vitamin K2 level and impedes preadipocyte differentiation.
      Title: The Vitamin K Epoxide Reductase Vkorc1l1 Promotes Preadipocyte Differentiation in Mice.
    4. quantified mRNA levels for VKORC1, VKORC1L1, GGCX, and NQO1 and measured VKOR enzymatic activities in 29 different tissues
      Title: Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain.
    5. The involvement of VKORC1L1 in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists.
      Title: VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
    6. molecular cloning
      Title: Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vitamin-K-epoxide reductase (warfarin-sensitive) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables vitamin-K-epoxide reductase (warfarin-sensitive) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables vitamin-K-epoxide reductase (warfarin-sensitive) activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables vitamin-K-epoxide reductase (warfarin-sensitive) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-glutamic acid carboxylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-glutamic acid carboxylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vitamin K metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vitamin K metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vitamin K metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within vitamin K metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vitamin K metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    vitamin K epoxide reductase complex subunit 1-like protein 1
    Names
    VKORC1-like protein 1
    NP_001001327.1
    NP_001273311.1
    NP_081397.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001327.2 → NP_001001327.1  vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001001327.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK033702, AK078942, BC085133, BE954096, CF533903, CK639505, CN457470
      Consensus CDS
      CCDS19704.1
      UniProtKB/TrEMBL
      Q0VGU5
      Related
      ENSMUSP00000144608.2, ENSMUST00000201855.2
      Conserved Domains (1) summary
      cl01729
      Location:18 → 65
      VKOR; Vitamin K epoxide reductase (VKOR) family

    2. NM_001286382.1 → NP_001273311.1  vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AK033702, AK078942, BC085133, BE954096, CF533903, CK639505, CN457470, CN701203
      Consensus CDS
      CCDS80417.1
      UniProtKB/TrEMBL
      A0A0M3HEP8, Q9D781
      Related
      ENSMUSP00000073601.6, ENSMUST00000073945.6
      Conserved Domains (1) summary
      cd12917
      Location:19 → 110
      VKOR_euk; Vitamin K epoxide reductase family in eukaryotes, excluding plants

    3. NM_027121.4 → NP_081397.1  vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_081397.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK033702, AK078942, BC085133, BE954096, CF533903, CK639505, CN457470, CN701203
      Consensus CDS
      CCDS19703.1
      UniProtKB/Swiss-Prot
      Q05AD4, Q6TEK5
      Related
      ENSMUSP00000059139.9, ENSMUST00000051758.11
      Conserved Domains (1) summary
      cd12917
      Location:18 → 156
      VKOR_euk; Vitamin K epoxide reductase family in eukaryotes, excluding plants

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      129970950..130015533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TEK5.1 GenPept UniProtKB/Swiss-Prot:Q6TEK5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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