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    PHT1;4 phosphate transporter 1;4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818479, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PHT1;4
    Official Full Name
    phosphate transporter 1;4
    Primary source
    TAIR:AT2G38940
    Locus tag
    AT2G38940
    See related
    Araport:AT2G38940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA PHOSPHATE TRANSPORTER 2; ATPT2; phosphate transporter 1;4; T7F6.11; T7F6_11
    Summary
    Encodes Pht1;4, a member of the Pht1 family of phosphate transporters which include: Pht1;1/At5g43350, Pht1;2/At5g43370, Pht1;3/At5g43360, Pht1;4/At2g38940, Pht1;5/At2g32830, Pht1;6/At5g43340, Pht1;7/At3g54700, Pht1;8/At1g20860, Pht1;9/At1g76430 (Plant Journal 2002, 31:341). Expression is upregulated in the shoot of cax1/cax3 mutant.
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    Genomic context

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    See PHT1;4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Sequence:
    Chromosome: 2; NC_003071.7 (16257157..16260253)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene calcium-dependent protein kinase 20 Neighboring gene SPX (SYG1/Pho81/XPR1) domain-containing protein / zinc finger (C3HC4-type RING finger) protein-like protein Neighboring gene Transcription factor jumonji (jmj) family protein / zinc finger (C5HC2 type) family protein Neighboring gene endoplasmic reticulum oxidoreductins 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Promoter deletion analysis elucidates the role of cis elements and 5'UTR intron in spatiotemporal regulation of AtPht1;4 expression in Arabidopsis. Karthikeyan AS, et al. Physiol Plant, 2009 May. PMID 19508364
    2. GTPase ROP6 negatively modulates phosphate deficiency through inhibition of PHT1;1 and PHT1;4 in Arabidopsis thaliana. Gao H, et al. J Integr Plant Biol, 2021 Oct. PMID 34288396
    3. Increased phosphate transport of Arabidopsis thaliana Pht1;1 by site-directed mutagenesis of tyrosine 312 may be attributed to the disruption of homomeric interactions. Fontenot EB, et al. Plant Cell Environ, 2015 Oct. PMID 25754174
    4. Identification of downstream components of ubiquitin-conjugating enzyme PHOSPHATE2 by quantitative membrane proteomics in Arabidopsis roots. Huang TK, et al. Plant Cell, 2013 Oct. PMID 24122829, Free PMC Article
    5. Nitrogen limitation adaptation, a target of microRNA827, mediates degradation of plasma membrane-localized phosphate transporters to maintain phosphate homeostasis in Arabidopsis. Lin WY, et al. Plant Cell, 2013 Oct. PMID 24122828, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GTPase ROP6 negatively modulates phosphate deficiency through inhibition of PHT1;1 and PHT1;4 in Arabidopsis thaliana.
      Title: GTPase ROP6 negatively modulates phosphate deficiency through inhibition of PHT1;1 and PHT1;4 in Arabidopsis thaliana.
    2. Pht1;1 and Pht1;4 form homomeric and heteromeric complexes. The homomeric interaction among Pht1;1 proteins was disrupted by mutation of Tyr 312 to Asp, but not to Ala or Phe. Modifications to the Pht1;1 higher-order structure affects Pi transport.
      Title: Increased phosphate transport of Arabidopsis thaliana Pht1;1 by site-directed mutagenesis of tyrosine 312 may be attributed to the disruption of homomeric interactions.
    3. The region containing the PHR1-binding site motif is essential for the basal expression of AtPht1;4 in the roots, but that it does not control the Pi responsiveness of AtPht1;4.
      Title: Promoter deletion analysis elucidates the role of cis elements and 5'UTR intron in spatiotemporal regulation of AtPht1;4 expression in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_129452.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    phosphate transporter 1;4
    NP_181428.1
    • phosphate transporter 1;4 (PHT1;4); FUNCTIONS IN: phosphate transmembrane transporter activity, carbohydrate transmembrane transporter activity, inorganic phosphate transmembrane transporter activity, sugar:hydrogen symporter activity; INVOLVED IN: transport, phosphate transport, transmembrane transport; LOCATED IN: nucleus, plasma membrane, vacuole, membrane; EXPRESSED IN: male gametophyte, cultured cell, pollen tube, leaf; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Major facilitator superfamily (InterPro:IPR020846), General substrate transporter (InterPro:IPR005828), Phosphate permease (InterPro:IPR004738), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: phosphate transporter 1;7 (TAIR:AT3G54700.1); Has 27225 Blast hits to 27133 proteins in 2002 species: Archae - 605; Bacteria - 19470; Metazoa - 1461; Fungi - 3457; Plants - 1450; Viruses - 2; Other Eukaryotes - 780 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16257157..16260253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129452.4 → NP_181428.1  phosphate transporter 1;4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181428.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q96303
      UniProtKB/TrEMBL
      A0A178VRB1, A0A5S9X5B7, A0A5S9XLL6, A0A654FH43
      Conserved Domains (1) summary
      TIGR00887
      Location:11 → 516
      2A0109; phosphate:H+ symporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96303.1

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