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    fumarylacetoacetase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837757, updated on 18-Sep-2024

    Summary

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    Official Full Name
    fumarylacetoacetase
    Primary source
    TAIR:AT1G12050
    Locus tag
    AT1G12050
    See related
    Araport:AT1G12050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtFAH; F12F1.8; F12F1_8; FAH; fumarylacetoacetate hydrolase; short-day sensitive cell deathshort-day sensitive cell deathshort-day sensitive cell death 111; SSCD1
    Summary
    Encodes a fumarylacetoacetase that converts fumarylacetoacetate to acetoacetate and fumarate and is likely to be involved in tyrosine catabolism.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    15
    Sequence:
    Chromosome: 1; NC_003070.9 (4072741..4076207)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene leucine-rich repeat/extensin 1 Neighboring gene BCL-2-associated athanogene 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fumarylacetoacetate hydrolase is involved in salt stress response in Arabidopsis. Huang L, et al. Planta, 2018 Aug. PMID 29785518
    2. Disruption of fumarylacetoacetate hydrolase causes spontaneous cell death under short-day conditions in Arabidopsis. Han C, et al. Plant Physiol, 2013 Aug. PMID 23743712, Free PMC Article
    3. Enzymes of tyrosine catabolism in Arabidopsis thaliana. Dixon DP, et al. Plant Sci, 2006 Sep. PMID 22980205
    4. Profiling of the Receptor for Activated C Kinase 1a (RACK1a) interaction network in Arabidopsis thaliana. Guo J, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31606202
    5. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101077.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables fumarylacetoacetase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within homogentisate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within tyrosine catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in extracellular region HDA PubMed 

    General protein information

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    Preferred Names
    fumarylacetoacetase
    NP_172669.2
    • fumarylacetoacetase, putative; FUNCTIONS IN: fumarylacetoacetase activity, catalytic activity; INVOLVED IN: aromatic amino acid family metabolic process, metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Fumarylacetoacetase, C-terminal-like (InterPro:IPR002529), Fumarylacetoacetase, C-terminal-related (InterPro:IPR011234), Fumarylacetoacetase, N-terminal (InterPro:IPR015377), Fumarylacetoacetase (InterPro:IPR005959); Has 4441 Blast hits to 4434 proteins in 1063 species: Archae - 139; Bacteria - 2814; Metazoa - 297; Fungi - 179; Plants - 60; Viruses - 0; Other Eukaryotes - 952 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4072741..4076207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101077.6 → NP_172669.2  fumarylacetoacetase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172669.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65374, Q8RW90
      UniProtKB/TrEMBL
      A0A654EAN4
      Conserved Domains (1) summary
      PLN02856
      Location:1 → 421
      PLN02856; fumarylacetoacetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8RW90.1

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