ABCB1 ATP binding cassette subfamily B1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ABCB1
Official Full Name: ATP binding cassette subfamily B1
Primary source: TAIR:AT2G36910
Locus tag: AT2G36910
See related: Araport:AT2G36910
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA P GLYCOPROTEIN1; ATP binding cassette subfamily B1; ATP-binding cassette B1; ATPGP1; P-GLYCOPROTEIN 1; PGP1; T1J8.9; T1J8_9
Summary: Belongs to the family of ATP-binding cassette (ABC) transporters. Also known as AtMDR1.Possibly regulates auxin-dependent responses by influencing basipetal auxin transport in the root. Exerts nonredundantly overlapping functions with the ABC transporter encoded by AT3G28860. PGP1 mediates cellular efflux of IAA and interacts with PIN genes that may confer an accelerated vectoral component to PGP-mediated transport. The non-polar localization of PGP1 at root and shoot apices, where IAA gradient-driven transport is impaired, may be required to confer directionality to auxin transport in those tissues.
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Genomic context

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See ABCB1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 10

Sequence:: Chromosome: 2; NC_003071.7 (15501726..15507501)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ABCB1 plays a major role during anther development, while ABCB19 has a synergistic role.
Title: ABCB1 and ABCB19 auxin transporters have synergistic effects on early and late Arabidopsis anther development.
TWD1 controls lateral ABCB1-mediated export into the apoplast, which is required for auxin-mediated cell elongation.
Title: Expression of TWISTED DWARF1 lacking its in-plane membrane anchor leads to increased cell elongation and hypermorphic growth.
These results suggest a direct involvement of AtPGP1 in auxin transport processes controlling plant growth
Title: Characterization of a dwarf mutant allele of Arabidopsis MDR-like ABC transporter AtPGP1 gene.
TWD1 promotes lateral ABCB-mediated auxin efflux via protein-protein interaction at the plasma membrane, minimizing reflux from the root apoplast into the cytoplasm.
Title: Arabidopsis TWISTED DWARF1 functionally interacts with auxin exporter ABCB1 on the root plasma membrane.
Evidence was provided that AGC protein kinase phosphorylation has a dual, counter-active impact on ABCB1 activity that is coordinated by TWD1-PID interaction.
Title: Regulation of ABCB1/PGP1-catalysed auxin transport by linker phosphorylation.
Data show that root hair cell-specific overexpression of auxin efflux transporter PGP1 decreased root hair elongation.
Title: P-glycoprotein4 displays auxin efflux transporter-like action in Arabidopsis root hair cells and tobacco cells.
The localization, activity, substrate specificity and inhibitor sensitivity of AtPGP1 are reported.
Title: Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1.
The functional characterization of two closely related ABC (ATP-binding cassette) transporter genes, AtMDR1 and AtPGP1, in light and auxin responses.
Title: Two homologous ATP-binding cassette transporter proteins, AtMDR1 and AtPGP1, regulate Arabidopsis photomorphogenesis and root development by mediating polar auxin transport.
Immunophilin-like TWISTED DWARF1 modulates auxin efflux activities of Arabidopsis P-glycoprotein
Title: Immunophilin-like TWISTED DWARF1 modulates auxin efflux activities of Arabidopsis P-glycoproteins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_129247.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables auxin efflux transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables auxin influx transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anthocyanin accumulation in tissues in response to UV light	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within auxin export across the plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within auxin polar transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within auxin polar transport	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within photomorphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive gravitropism	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to auxin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to blue light	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to nematode	HEP more info	PubMed
acts_upstream_of_or_within response to red or far red light	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stamen development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: ATP binding cassette subfamily B1

NP_181228.1

ATP binding cassette subfamily B1 (ABCB1); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances, calmodulin binding, auxin efflux transmembrane transporter activity; INVOLVED IN: in 10 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: ATP binding cassette subfamily B19 (TAIR:AT3G28860.1); Has 825599 Blast hits to 386427 proteins in 4134 species: Archae - 14573; Bacteria - 644325; Metazoa - 17752; Fungi - 12077; Plants - 9020; Viruses - 35; Other Eukaryotes - 127817 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

15501726..15507501

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129247.3 → NP_181228.1 ATP binding cassette subfamily B1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181228.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8L6X6, Q9ZR72

UniProtKB/TrEMBL

A0A178VPM1

Conserved Domains (3) summary

cd03249
Location:368 → 607

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

PTZ00265
Location:43 → 1264

PTZ00265; multidrug resistance protein (mdr1); Provisional

pfam00664
Location:49 → 319

ABC_membrane; ABC transporter transmembrane region