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    ADT1 arogenate dehydratase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837725, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ADT1
    Official Full Name
    arogenate dehydratase 1
    Primary source
    TAIR:AT1G11790
    Locus tag
    AT1G11790
    See related
    Araport:AT1G11790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana arogenate dehydratase 1; arogenate dehydratase 1; AtADT1; F25C20.4; F25C20_4
    Summary
    Encodes a plastid-localized arogenate dehydratase involved in phenylalanine biosynthesis. Not less than six genes encoding ADT were identified in the Arabidopsis genome: ADT1 [At1g11790]; ADT2 [At3g07630]; ADT3 [At2g27820]; ADT4 [At3g44720]; ADT5 [At5g22630]; and ADT6 [At1g08250].
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    Genomic context

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    See ADT1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (3981153..3985219)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene FAD-binding Berberine family protein Neighboring gene ncRNA Neighboring gene oxidoreductase, 2OG-Fe(II) oxygenase family protein Neighboring gene uncharacterized protein Neighboring gene endonuclease/exonuclease/phosphatase family protein Neighboring gene miscRNA Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complementation of the pha2 yeast mutant suggests functional differences for arogenate dehydratases from Arabidopsis thaliana. Bross CD, et al. Plant Physiol Biochem, 2011 Aug. PMID 21388819
    2. Tyrosine and phenylalanine are synthesized within the plastids in Arabidopsis. Rippert P, et al. Plant Physiol, 2009 Mar. PMID 19136569, Free PMC Article
    3. Phenylalanine biosynthesis in Arabidopsis thaliana. Identification and characterization of arogenate dehydratases. Cho MH, et al. J Biol Chem, 2007 Oct 19. PMID 17726025
    4. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADT1 can use prephenate as a substrate and can function as a prephenate dehydratase
      Title: Complementation of the pha2 yeast mutant suggests functional differences for arogenate dehydratases from Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001035947.1
    NM_101051.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables arogenate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables prephenate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-phenylalanine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    arogenate dehydratase 1
    NP_001031024.1
    • arogenate dehydratase 1 (ADT1); FUNCTIONS IN: arogenate dehydratase activity, prephenate dehydratase activity; INVOLVED IN: L-phenylalanine biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Prephenate dehydratase (InterPro:IPR001086), Prephenate dehydratase, conserved site (InterPro:IPR018528); BEST Arabidopsis thaliana protein match is: arogenate dehydratase 2 (TAIR:AT3G07630.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_172644.1
    • arogenate dehydratase 1 (ADT1); FUNCTIONS IN: arogenate dehydratase activity, prephenate dehydratase activity; INVOLVED IN: L-phenylalanine biosynthetic process, metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Prephenate dehydratase (InterPro:IPR001086), Amino acid-binding ACT (InterPro:IPR002912), Prephenate dehydratase, conserved site (InterPro:IPR018528); BEST Arabidopsis thaliana protein match is: arogenate dehydratase 2 (TAIR:AT3G07630.2); Has 7165 Blast hits to 7163 proteins in 2224 species: Archae - 179; Bacteria - 3955; Metazoa - 5; Fungi - 120; Plants - 260; Viruses - 0; Other Eukaryotes - 2646 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3981153..3985219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101051.3 → NP_172644.1  arogenate dehydratase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172644.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2V4P0, Q94B20, Q9SA96
      UniProtKB/TrEMBL
      A0A178W336, A0A5S9TW43, A0A654E8X2
      Conserved Domains (1) summary
      PLN02317
      Location:12 → 389
      PLN02317; arogenate dehydratase

    2. NM_001035947.1 → NP_001031024.1  arogenate dehydratase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031024.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9TW43, A0A654E8X2
      Conserved Domains (3) summary
      PLN02317
      Location:12 → 328
      PLN02317; arogenate dehydratase
      cd13631
      Location:105 → 284
      PBP2_Ct-PDT_like; Catalytic domain of prephenate dehydratase from Chlorobium tepidum and similar proteins, subgroup 2; the type 2 periplasmic binding protein fold
      cl09141
      Location:294 → 327
      ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SA96.1

    Gene LinkOut

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