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    TADA tRNA arginine adenosine deaminase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843202, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TADA
    Official Full Name
    tRNA arginine adenosine deaminase
    Primary source
    TAIR:AT1G68720
    Locus tag
    AT1G68720
    See related
    Araport:AT1G68720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA TRNA ADENOSINE DEAMINASE A; ATTADA; F24J5.5; F24J5_5; tRNA arginine adenosine deaminase
    Summary
    Encodes the chloroplastic A-to-I tRNA editing enzyme.
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    Genomic context

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    See TADA in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (25804392..25809031)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ATPase E1-E2 type family protein / haloacid dehalogenase-like hydrolase family protein Neighboring gene uncharacterized protein Neighboring gene Zim17-type zinc finger protein Neighboring gene arabinogalactan protein 19

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Plastidial DIG5 Protein Affects Lateral Root Development by Regulating Flavonoid Biosynthesis and Auxin Transport in Arabidopsis. Liu W, et al. Int J Mol Sci, 2022 Sep 13. PMID 36142550, Free PMC Article
    2. Arabidopsis tRNA adenosine deaminase arginine edits the wobble nucleotide of chloroplast tRNAArg(ACG) and is essential for efficient chloroplast translation. Delannoy E, et al. Plant Cell, 2009 Jul. PMID 19602623, Free PMC Article
    3. Identification of the chloroplast adenosine-to-inosine tRNA editing enzyme. Karcher D, et al. RNA, 2009 Jul. PMID 19460869, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disruption of TADA has profound effects on chloroplast translation efficiency, leading to reduced yields of chloroplast-encoded proteins and impaired photosynthetic function.
      Title: Arabidopsis tRNA adenosine deaminase arginine edits the wobble nucleotide of chloroplast tRNAArg(ACG) and is essential for efficient chloroplast translation.
    Submit: New GeneRIF Correction

    General gene information

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    NM_105544.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables tRNA-specific adenosine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA-specific adenosine deaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA-specific adenosine-34 deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lateral root formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tRNA wobble adenosine to inosine editing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within tRNA wobble adenosine to inosine editing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    tRNA arginine adenosine deaminase
    NP_177039.1
    • tRNA arginine adenosine deaminase (TADA); FUNCTIONS IN: hydrolase activity, tRNA-specific adenosine deaminase activity, zinc ion binding; INVOLVED IN: tRNA wobble adenosine to inosine editing; LOCATED IN: chloroplast, plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: CMP/dCMP deaminase, zinc-binding (InterPro:IPR002125), Cytidine deaminase-like (InterPro:IPR016193); BEST Arabidopsis thaliana protein match is: Cytidine/deoxycytidylate deaminase family protein (TAIR:AT5G28050.1); Has 24755 Blast hits to 21172 proteins in 2784 species: Archae - 180; Bacteria - 9362; Metazoa - 5238; Fungi - 1033; Plants - 641; Viruses - 59; Other Eukaryotes - 8242 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      25804392..25809031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105544.3 → NP_177039.1  tRNA arginine adenosine deaminase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177039.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GY37, Q9S7I0
      UniProtKB/TrEMBL
      A0A178W371, A0A5S9WSS3
      Conserved Domains (1) summary
      COG0590
      Location:1110 → 1268
      TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S7I0.1

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