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    MTO1 Pyridoxal phosphate (PLP)-dependent transferases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821292, updated on 18-Sep-2024

    Summary

    Official Symbol
    MTO1
    Official Full Name
    Pyridoxal phosphate (PLP)-dependent transferases superfamily protein
    Primary source
    TAIR:AT3G01120
    Locus tag
    AT3G01120
    See related
    Araport:AT3G01120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    A. THALIANA CYSTATHIONINE GAMMA-SYNTHASE 1; A. thaliana cystathionine gamma-synthetase 1; AtCGS1; AtCYS1; ATCYS1; CGS; CGS1; CYSTATHIONINE GAMMA-SYNTHASE; CYSTATHIONINE GAMMA-SYNTHASE 1; CYSTATHIONINE-GAMMA-SYNTHASE; METHIONINE OVERACCUMULATION 1; T4P13.19; T4P13_19
    Summary
    encodes a cystathionine gamma-synthase, which performs the first committed step in methionine biosynthesis. A conserved motif of 13 amino acids in the first exon is required for posttranscriptional autoregulation. This enzyme shares the same substrate as threonine synthase (TS) and its absence transcriptionally affects 8 genes in the genome.
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    Genomic context

    See MTO1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (38759..42159, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene SNF1 kinase homolog 10 Neighboring gene hypothetical protein 1 Neighboring gene ATP synthase E chain Neighboring gene ncRNA Neighboring gene myb domain protein 106

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    NM_110977.3

    Gene Ontology Provided by TAIR

    General protein information

    Preferred Names
    Pyridoxal phosphate (PLP)-dependent transferases superfamily protein
    NP_186761.1
    • METHIONINE OVERACCUMULATION 1 (MTO1); FUNCTIONS IN: cystathionine gamma-synthase activity; INVOLVED IN: methionine biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Cys/Met metabolism, pyridoxal phosphate-dependent enzyme (InterPro:IPR000277), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: Pyridoxal phosphate (PLP)-dependent transferases superfamily protein (TAIR:AT1G33320.1); Has 21364 Blast hits to 20702 proteins in 2452 species: Archae - 220; Bacteria - 11705; Metazoa - 241; Fungi - 842; Plants - 284; Viruses - 13; Other Eukaryotes - 8059 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      38759..42159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_110977.3 → NP_186761.1  Pyridoxal phosphate (PLP)-dependent transferases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_186761.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P55217, P92944, P93038, Q42550
      UniProtKB/TrEMBL
      A0A178VB36, A0A5S9X8A2, A0A7G2EL88
      Conserved Domains (1) summary
      pfam01053
      Location:176 → 561
      Cys_Met_Meta_PP; Cys/Met metabolism PLP-dependent enzyme
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