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    MEE32 dehydroquinate dehydratase, putative / shikimate dehydrogenase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819809, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MEE32
    Official Full Name
    dehydroquinate dehydratase, putative / shikimate dehydrogenase
    Primary source
    TAIR:AT3G06350
    Locus tag
    AT3G06350
    See related
    Araport:AT3G06350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EMB3004; EMBRYO DEFECTIVE 3004; F24P17.18; F24P17_18; MATERNAL EFFECT EMBRYO ARREST 32
    Summary
    Encodes a bi-functional dehydroquinate-shikimate dehydrogenase enzyme that catalyzes two steps in the chorismate biosynthesis pathway.
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    Genomic context

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    See MEE32 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (1924270..1927850, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene tRNA-Pro Neighboring gene DNAJ heat shock N-terminal domain-containing protein Neighboring gene arabinogalactan protein 27 Neighboring gene sodium hydrogen exchanger 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of Arabidopsis dehydroquinate dehydratase-shikimate dehydrogenase and implications for metabolic channeling in the shikimate pathway. Singh SA, et al. Biochemistry, 2006 Jun 27. PMID 16784230
    2. Genetic and molecular identification of genes required for female gametophyte development and function in Arabidopsis. Pagnussat GC, et al. Development, 2005 Feb. PMID 15634699
    3. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article
    4. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475
    5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_111510.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3-dehydroquinate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		  
    enables 3-dehydroquinate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables shikimate 3-dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chorismate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within shikimate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dehydroquinate dehydratase, putative / shikimate dehydrogenase
    NP_187286.1
    • MATERNAL EFFECT EMBRYO ARREST 32 (MEE32); FUNCTIONS IN: NADP or NADPH binding, 3-dehydroquinate dehydratase activity, shikimate 5-dehydrogenase activity, binding, catalytic activity; INVOLVED IN: embryo development ending in seed dormancy; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase (InterPro:IPR006151), Aldolase-type TIM barrel (InterPro:IPR013785), Quinate/shikimate 5-dehydrogenase (InterPro:IPR011342), NAD(P)-binding domain (InterPro:IPR016040), Dehydroquinase class I (InterPro:IPR001381), Shikimate dehydrogenase substrate binding, N-terminal (InterPro:IPR013708); Has 14455 Blast hits to 14453 proteins in 2669 species: Archae - 507; Bacteria - 10604; Metazoa - 0; Fungi - 391; Plants - 114; Viruses - 0; Other Eukaryotes - 2839 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1924270..1927850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111510.4 → NP_187286.1  dehydroquinate dehydratase, putative / shikimate dehydrogenase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187286.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3ZLP7, Q56ZH7, Q6NLY1, Q9SQT8
      UniProtKB/TrEMBL
      A0A178VBC4, A0A5S9XAA2
      Conserved Domains (1) summary
      PLN02520
      Location:72 → 603
      PLN02520; bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SQT8.1

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