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    ICL isocitrate lyase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821726, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ICL
    Official Full Name
    isocitrate lyase
    Primary source
    TAIR:AT3G21720
    Locus tag
    AT3G21720
    See related
    Araport:AT3G21720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    isocitrate lyase
    Summary
    Encodes a glyoxylate cycle enzyme isocitrate lyase (ICL).
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    Genomic context

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    See ICL in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (7652487..7656053, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Ras-related small GTP-binding family protein Neighboring gene uncharacterized protein Neighboring gene Dihydroneopterin aldolase Neighboring gene APO RNA-binding protein (DUF794)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Peroxisome-associated matrix protein degradation in Arabidopsis. Lingard MJ, et al. Proc Natl Acad Sci U S A, 2009 Mar 17. PMID 19246395, Free PMC Article
    2. Postgerminative growth and lipid catabolism in oilseeds lacking the glyoxylate cycle. Eastmond PJ, et al. Proc Natl Acad Sci U S A, 2000 May 9. PMID 10805817, Free PMC Article
    3. Direct interaction and determination of binding domains among peroxisomal import factors in Arabidopsis thaliana. Nito K, et al. Plant Cell Physiol, 2002 Apr. PMID 11978862
    4. VH1/BRL2 receptor-like kinase interacts with vascular-specific adaptor proteins VIT and VIK to influence leaf venation. Ceserani T, et al. Plant J, 2009 Mar. PMID 19000166, Free PMC Article
    5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_113067.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables isocitrate lyase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glyoxylate cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glyoxylate cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in glyoxysome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isocitrate lyase
    NP_188809.2
    • isocitrate lyase (ICL); FUNCTIONS IN: isocitrate lyase activity, catalytic activity; INVOLVED IN: carboxylic acid metabolic process, metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: leaf whorl, seed, leaf; CONTAINS InterPro DOMAIN/s: Isocitrate lyase/phosphorylmutase, conserved site (InterPro:IPR018523), Pyruvate/Phosphoenolpyruvate kinase, catalytic core (InterPro:IPR015813), Isocitrate lyase (InterPro:IPR006254), Isocitrate lyase/phosphorylmutase (InterPro:IPR000918); BEST Arabidopsis thaliana protein match is: Phosphoenolpyruvate carboxylase family protein (TAIR:AT1G77060.1); Has 9953 Blast hits to 7473 proteins in 1388 species: Archae - 150; Bacteria - 5572; Metazoa - 28; Fungi - 504; Plants - 171; Viruses - 0; Other Eukaryotes - 3528 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7652487..7656053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113067.4 → NP_188809.2  isocitrate lyase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188809.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P28297, Q41948, Q9LSZ2
      UniProtKB/TrEMBL
      A0A178VFU1, A0A384KC84, A0A5S9XEX2, A0A654F9F4, Q0WWE9
      Conserved Domains (1) summary
      PLN02892
      Location:1 → 576
      PLN02892; isocitrate lyase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28297.2

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