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    AFH1 formin homology 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822136, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AFH1
    Official Full Name
    formin homology 1
    Primary source
    TAIR:AT3G25500
    Locus tag
    AT3G25500
    See related
    Araport:AT3G25500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AHF1; ARABIDOPSIS THALIANA FORMIN HOMOLOGY 1; ATFH1; FH1; formin homology 1; FORMIN HOMOLOGY 1; FORMIN-LIKE PROTEIN AHF1
    Summary
    Poly-L-proline-containing (PLP) protein that form part of the signal-transduction cascade that leads to rearrangement of the actin cytoskeleton. AFH1 is a nonprocessive formin that moves from the barbered end to the side of an actin filament after the nucleation event.
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    Genomic context

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    See AFH1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (9251093..9255083, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Protein kinase family protein Neighboring gene formin-like protein Neighboring gene miscRNA Neighboring gene TIR-NBS-LRR class disease resistance protein Neighboring gene disease resistance protein (TIR-NBS-LRR class) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis FH1 Formin Affects Cotyledon Pavement Cell Shape by Modulating Cytoskeleton Dynamics. Rosero A, et al. Plant Cell Physiol, 2016 Mar. PMID 26738547
    2. Building bridges: formin1 of Arabidopsis forms a connection between the cell wall and the actin cytoskeleton. Martinière A, et al. Plant J, 2011 Apr. PMID 21241388
    3. A novel mechanism for the formation of actin-filament bundles by a nonprocessive formin. Michelot A, et al. Curr Biol, 2006 Oct 10. PMID 17027489
    4. An Arabidopsis class II formin, AtFH19, nucleates actin assembly, binds to the barbed end of actin filaments, and antagonizes the effect of AtFH1 on actin dynamics. Zheng Y, et al. J Integr Plant Biol, 2012 Oct. PMID 22947203
    5. The formin homology 1 domain modulates the actin nucleation and bundling activity of Arabidopsis FORMIN1. Michelot A, et al. Plant Cell, 2005 Aug. PMID 15994911, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FH1 participates in the control of microtubule dynamics, possibly via its effects on actin, subsequently influencing cell morphogenesis and macroscopic organ development.
      Title: Arabidopsis FH1 Formin Affects Cotyledon Pavement Cell Shape by Modulating Cytoskeleton Dynamics.
    2. AtFH1 forms a link between the actin cytoskeleton and the cell wall.
      Title: Building bridges: formin1 of Arabidopsis forms a connection between the cell wall and the actin cytoskeleton.
    3. AFH1 is a nonprocessive formin that moves from the barbed end to the side of an actin filament after the nucleation event.
      Title: A novel mechanism for the formation of actin-filament bundles by a nonprocessive formin.
    4. Arabidopsis fh1/fhy1 double mutants reveal a distinct cytoplasmic action of phytochrome A.
      Title: Arabidopsis fhl/fhy1 double mutant reveals a distinct cytoplasmic action of phytochrome A.
    5. Overexpression of AFH1 in pollen tubes has been shown previously to induce abnormal actin cable formation. AFH1 plays a central role in the initiation and organization of actin cables from the pool of actin monomers bound to profilin. [FORMIN1] [AFH1]
      Title: The formin homology 1 domain modulates the actin nucleation and bundling activity of Arabidopsis FORMIN1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_113446.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within actin nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within barbed-end actin filament capping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with plasmodesma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    formin homology 1
    NP_189177.1
    • formin homology 1 (AFH1); FUNCTIONS IN: actin binding, protein binding, actin filament binding; INVOLVED IN: actin cytoskeleton organization; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Actin-binding FH2/DRF autoregulatory (InterPro:IPR003104), Actin-binding FH2 (InterPro:IPR015425); BEST Arabidopsis thaliana protein match is: Actin-binding FH2 (formin homology 2) family protein (TAIR:AT2G43800.1); Has 17339 Blast hits to 10806 proteins in 665 species: Archae - 8; Bacteria - 1434; Metazoa - 6069; Fungi - 2556; Plants - 3390; Viruses - 718; Other Eukaryotes - 3164 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      9251093..9255083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113446.5 → NP_189177.1  formin homology 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189177.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WVK4, Q9SE97
      UniProtKB/TrEMBL
      A0A178VBY1, A0A5S9XFI8
      Conserved Domains (1) summary
      pfam02181
      Location:591 → 985
      FH2; Formin Homology 2 Domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SE97.1

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