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    POLGAMMA1 polymerase gamma 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821600, updated on 18-Sep-2024

    Summary

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    Official Symbol
    POLGAMMA1
    Official Full Name
    polymerase gamma 1
    Primary source
    TAIR:AT3G20540
    Locus tag
    AT3G20540
    See related
    Araport:AT3G20540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    PolIB; polymerase gamma 1; polymerase I B
    Summary
    Encodes an organellar DNA polymerase I that is also involved in double strand break repair.
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    Genomic context

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    See POLGAMMA1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Sequence:
    Chromosome: 3; NC_003074.8 (7168054..7173617)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Transmembrane proteins 14C Neighboring gene SHV3-like 3 Neighboring gene Protein kinase superfamily protein Neighboring gene miscRNA Neighboring gene SMAD/FHA domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis thaliana organellar DNA polymerase IB mutants exhibit reduced mtDNA levels with a decrease in mitochondrial area density. Cupp JD, et al. Physiol Plant, 2013 Sep. PMID 23167278
    2. Identification of a unique insertion in plant organellar DNA polymerases responsible for 5'-dRP lyase and strand-displacement activities: Implications for Base Excision Repair. Trasviña-Arenas CH, et al. DNA Repair (Amst), 2018 May. PMID 29522990
    3. Plant organellar DNA polymerases are replicative and translesion DNA synthesis polymerases. Baruch-Torres N, et al. Nucleic Acids Res, 2017 Oct 13. PMID 28977655, Free PMC Article
    4. Divergent roles for the two PolI-like organelle DNA polymerases of Arabidopsis. Parent JS, et al. Plant Physiol, 2011 May. PMID 21427281, Free PMC Article
    5. AtPolλ, a homolog of mammalian DNA polymerase λ in Arabidopsis thaliana, is involved in the repair of UV-B induced DNA damage through the dark repair pathway. Roy S, et al. Plant Cell Physiol, 2011 Feb. PMID 21227935

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The interaction of Twinkle with Pol1A or Pol1B mimics the minimal DNA replisomes of T7 phage and those present in mammalian mitochondria. However, while T7 and mammals absolutely require their homolog of Twinkle DNA helicase-primase, Arabidopsis Twinkle mutants are seemingly unaffected by this loss.
      Title: Arabidopsis thaliana organelles mimic the T7 phage DNA replisome with specific interactions between Twinkle protein and DNA polymerases Pol1A and Pol1B.
    2. PolIA & PolIB are functionally equipped to play a role in short-patch BER and suggest a major role of PolIA & PolIB in a predicted long-patch base excision repair (BER) sub-pathway. We propose that the acquisition of insertion 1 in the polymerization domain of PolIA & PolIB was a key component in their evolution as BER associated and replicative DNA polymerases.
      Title: Identification of a unique insertion in plant organellar DNA polymerases responsible for 5'-dRP lyase and strand-displacement activities: Implications for Base Excision Repair.
    3. both AtPolIA and AtPolIB are efficient translesion DNA synthesis polymerases, providing the first example of a family-A DNAP with an active exonuclease domain that efficiently bypasses an AP site.
      Title: Plant organellar DNA polymerases are replicative and translesion DNA synthesis polymerases.
    4. results suggest that polIB (At3G29540) mutants undergo an adjustment in cell homeostasis, enabling them to maintain functional mitochondria at the cost of normal cell expansion and plant growth
      Title: Arabidopsis thaliana organellar DNA polymerase IB mutants exhibit reduced mtDNA levels with a decrease in mitochondrial area density.
    5. UV-B irradiation enhances expression of AtPollambda in wild-type Arabidopsis. Overexpression partially complements DNA damage repair efficiency of atpollambda mutants.
      Title: AtPolλ, a homolog of mammalian DNA polymerase λ in Arabidopsis thaliana, is involved in the repair of UV-B induced DNA damage through the dark repair pathway.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001203013.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrial DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plastid DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plastid DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast nucleoid HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    polymerase gamma 1
    NP_001189942.1
    • polymerase gamma 1 (POLGAMMA1); FUNCTIONS IN: 3'-5' exonuclease activity, DNA-directed DNA polymerase activity, DNA binding, nucleic acid binding; INVOLVED IN: DNA replication, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: male gametophyte; EXPRESSED DURING: M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family A, palm domain (InterPro:IPR001098), DNA polymerase A domain (InterPro:IPR002298), 3'-5' exonuclease (InterPro:IPR002562); BEST Arabidopsis thaliana protein match is: polymerase gamma 2 (TAIR:AT1G50840.1).
    NP_188690.3
    • polymerase gamma 1 (POLGAMMA1); FUNCTIONS IN: 3'-5' exonuclease activity, DNA binding, DNA-directed DNA polymerase activity, nucleic acid binding; INVOLVED IN: DNA replication, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; LOCATED IN: mitochondrion, chloroplast, nucleoid; EXPRESSED IN: male gametophyte; EXPRESSED DURING: M germinated pollen stage; CONTAINS InterPro DOMAIN/s: DNA-directed DNA polymerase, family A, palm domain (InterPro:IPR001098), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA polymerase A domain (InterPro:IPR002298), 3'-5' exonuclease (InterPro:IPR002562); BEST Arabidopsis thaliana protein match is: polymerase gamma 2 (TAIR:AT1G50840.1); Has 12537 Blast hits to 10327 proteins in 2621 species: Archae - 0; Bacteria - 7030; Metazoa - 148; Fungi - 0; Plants - 126; Viruses - 345; Other Eukaryotes - 4888 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7168054..7173617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112946.5 → NP_188690.3  polymerase gamma 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188690.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84ND9, Q9LJU4
      UniProtKB/TrEMBL
      A0A5S9XE29, A0A654F922
      Conserved Domains (3) summary
      cd08640
      Location:618 → 1032
      DNA_pol_A_plastid_like; DNA polymerase A type from plastids of higher plants possibly involve in DNA replication or in the repair of errors occurring during replication
      cd06139
      Location:264 → 501
      DNA_polA_I_Ecoli_like_exo; DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases
      COG0749
      Location:252 → 1034
      PolA; DNA polymerase I - 3'-5' exonuclease and polymerase domains [Replication, recombination and repair]

    2. NM_001203013.1 → NP_001189942.1  polymerase gamma 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189942.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XE29, A0A654F922, F4JEQ3
      Conserved Domains (3) summary
      cd08640
      Location:633 → 1047
      DNA_pol_A_plastid_like; DNA polymerase A type from plastids of higher plants possibly involve in DNA replication or in the repair of errors occurring during replication
      cd06139
      Location:279 → 516
      DNA_polA_I_Ecoli_like_exo; DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases
      COG0749
      Location:267 → 1049
      PolA; DNA polymerase I - 3'-5' exonuclease and polymerase domains [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84ND9.1

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