FMO1 flavin-dependent monooxygenase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: FMO1
Official Full Name: flavin-dependent monooxygenase 1
Primary source: TAIR:AT1G19250
Locus tag: AT1G19250
See related: Araport:AT1G19250
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: flavin-dependent monooxygenase 1; T29M8.12; T29M8_12
Summary: FMO1 is required for full expression of TIR-NB-LRR-conditioned resistance to avirulent pathogens and for basal resistance to invasive virulent pathogens. Functions in an EDS1-regulated but SA-independent mechanism that promotes resistance and cell death at pathogen infection sites.
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

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FMO1 Is Involved in Excess Light Stress-Induced Signal Transduction and Cell Death Signaling.
Title: FMO1 Is Involved in Excess Light Stress-Induced Signal Transduction and Cell Death Signaling.
The isolation and characterization of a class 3 flavin-containing mono-oxygenase (FMO1) in A. thaliana is reported.
Title: A role for a flavin-containing mono-oxygenase in resistance against microbial pathogens in Arabidopsis.
The FMO1 gene product in systemic tissue is critical for the development of systemic acquired resistance (SAR).
Title: The Arabidopsis flavin-dependent monooxygenase FMO1 is an essential component of biologically induced systemic acquired resistance.
FMO1 and NUDT7 are important for signaling through an EDS1-dependent but SA-independent branch of plant defense and FMO1 positively regulates the EDS1 pathway. [FMO1]
Title: Salicylic acid-independent ENHANCED DISEASE SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_101783.4

Function	Evidence Code	Pubs
enables N,N-dimethylaniline monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables peptidyl-proline dioxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pipecolic acid N-hydroxylase	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-pipecolic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type hypersensitive response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to other organism	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within systemic acquired resistance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within systemic acquired resistance	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info

NP_173359.3

flavin-dependent monooxygenase 1 (FMO1); FUNCTIONS IN: NADP or NADPH binding, oxidoreductase activity, monooxygenase activity, FAD binding, flavin-containing monooxygenase activity; INVOLVED IN: in 7 processes; LOCATED IN: endomembrane system, intrinsic to endoplasmic reticulum membrane; EXPRESSED IN: stem, leaf whorl, sepal, root, stamen; EXPRESSED DURING: 4 anthesis; CONTAINS InterPro DOMAIN/s: Dimethylaniline monooxygenase, N-oxide-forming (InterPro:IPR012143), Flavin-containing amine oxidase (InterPro:IPR001613), Flavin-containing monooxygenase-like (InterPro:IPR020946); BEST Arabidopsis thaliana protein match is: Flavin-binding monooxygenase family protein (TAIR:AT5G45180.1); Has 7639 Blast hits to 7432 proteins in 837 species: Archae - 6; Bacteria - 3396; Metazoa - 753; Fungi - 1311; Plants - 833; Viruses - 0; Other Eukaryotes - 1340 (source: NCBI BLink).

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