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    SQS2 squalene synthase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829617, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SQS2
    Official Full Name
    squalene synthase 2
    Primary source
    TAIR:AT4G34650
    Locus tag
    AT4G34650
    See related
    Araport:AT4G34650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    squalene synthase 2; T4L20.230; T4L20_230
    Summary
    Encodes a protein with similarity to squalene synthase which catalyzes the first committed step in sterol biosynthesis. To date no experimental evidence exists that SQS2 functions as a squalene synthase and some experiments indicate it does not have this function.
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    Genomic context

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    See SQS2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    13
    Sequence:
    Chromosome: 4; NC_003075.7 (16542242..16545194)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene prostatic spermine-binding-like protein Neighboring gene squalene synthase 1 Neighboring gene SH3 domain-containing protein Neighboring gene Ribosomal protein S3Ae Neighboring gene GATA transcription factor 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis thaliana contains a single gene encoding squalene synthase. Busquets A, et al. Plant Mol Biol, 2008 May. PMID 18236008
    2. Cloning and characterization of the Arabidopsis thaliana SQS1 gene encoding squalene synthase--involvement of the C-terminal region of the enzyme in the channeling of squalene through the sterol pathway. Kribii R, et al. Eur J Biochem, 1997 Oct 1. PMID 9363754
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001342298.1
    NM_119631.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables farnesyltranstransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables squalene synthase [NAD(P)H] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables squalene synthase [NAD(P)H] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables squalene synthase [NAD(P)H] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables squalene synthase [NAD(P)H] activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables squalene synthase [NAD(P)H] activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sterol biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    squalene synthase 2
    NP_195191.2
    • squalene synthase 2 (SQS2); FUNCTIONS IN: farnesyl-diphosphate farnesyltransferase activity; INVOLVED IN: N-terminal protein myristoylation, sterol biosynthetic process; LOCATED IN: integral to membrane; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Terpenoid synthase (InterPro:IPR008949), Farnesyl-diphosphate farnesyltransferase (InterPro:IPR006449), Squalene/phytoene synthase (InterPro:IPR002060); BEST Arabidopsis thaliana protein match is: squalene synthase 1 (TAIR:AT4G34640.1); Has 1176 Blast hits to 1175 proteins in 496 species: Archae - 34; Bacteria - 579; Metazoa - 114; Fungi - 168; Plants - 163; Viruses - 0; Other Eukaryotes - 118 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16542242..16545194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119631.3 → NP_195191.2  squalene synthase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195191.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23118, O65688
      UniProtKB/TrEMBL
      A0A178V1Q0, A0A5S9Y0U9
      Conserved Domains (1) summary
      cl00210
      Location:35 → 369
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1

    2. NM_001342298.1 → NP_001328690.1  squalene synthase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B5E4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65688.2

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