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    PMR5 Pmr5/Cas1p GDSL/SGNH-like acyl-esterase family protein (DUF828) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835974, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PMR5
    Official Full Name
    Pmr5/Cas1p GDSL/SGNH-like acyl-esterase family protein (DUF828)
    Primary source
    TAIR:AT5G58600
    Locus tag
    AT5G58600
    See related
    Araport:AT5G58600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MZN1.6; MZN1_6; POWDERY MILDEW RESISTANT 5; TBL44; TRICHOME BIREFRINGENCE-LIKE 44
    Summary
    Belongs to a large family of plant-specific genes of unknown function. Involved in resistance to the powdery mildew species Erysiphe cichoracearum and Erysiphe orontii, but not to the unrelated pathogens Pseudomonas syringae or Peronospora parasitica. A member of the TBL (TRICHOME BIREFRINGENCE-LIKE) gene family containing a plant-specific DUF231 (domain of unknown function) domain. TBL gene family has 46 members, two of which (TBR/AT5G06700 and TBL3/AT5G01360) have been shown to be involved in the synthesis and deposition of secondary wall cellulose, presumably by influencing the esterification state of pectic polymers. A nomenclature for this gene family has been proposed (Volker Bischoff & Wolf Scheible, 2010, personal communication).
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    Genomic context

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    See PMR5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (23683784..23685831, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PHD finger transcription factor Neighboring gene zinc finger (CCCH-type) family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PMR5, an acetylation protein at the intersection of pectin biosynthesis and defense against fungal pathogens. Chiniquy D, et al. Plant J, 2019 Dec. PMID 31411777
    2. Mutations in PMR5 result in powdery mildew resistance and altered cell wall composition. Vogel JP, et al. Plant J, 2004 Dec. PMID 15584961
    3. AGB1 and PMR5 contribute to PEN2-mediated preinvasion resistance to Magnaporthe oryzae in Arabidopsis thaliana. Maeda K, et al. Mol Plant Microbe Interact, 2009 Nov. PMID 19810803
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis mutant powdery mildew resistant 5 (pmr5) carries a mutation in a putative pectin acetyltransferase gene that confers enhanced resistance to powdery mildew. Heterologously expressed PMR5 protein transfers acetyl groups from [(14) C]-acetyl-CoA to oligogalacturonides. In direct contrast to their increased powdery mildew resistance, both pmr5 and pmr6 plants are highly susceptibile to the necrotroph Botrytis.
      Title: PMR5, an acetylation protein at the intersection of pectin biosynthesis and defense against fungal pathogens.
    2. Double mutant analysis indicated that AGB1 and PMR5 contribute to PEN2-mediated preinvasion resistance to M. oryzae in A. thaliana, suggesting a complex genetic network regulating the resistance.
      Title: AGB1 and PMR5 contribute to PEN2-mediated preinvasion resistance to Magnaporthe oryzae in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    NM_125247.4
    NM_203232.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables O-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Pmr5/Cas1p GDSL/SGNH-like acyl-esterase family protein (DUF828)
    NP_200668.1
    • POWDERY MILDEW RESISTANT 5 (PMR5); CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF231, plant (InterPro:IPR004253); BEST Arabidopsis thaliana protein match is: TRICHOME BIREFRINGENCE-LIKE 45 (TAIR:AT2G30010.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_974961.1
    • POWDERY MILDEW RESISTANT 5 (PMR5); CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF231, plant (InterPro:IPR004253); BEST Arabidopsis thaliana protein match is: TRICHOME BIREFRINGENCE-LIKE 45 (TAIR:AT2G30010.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23683784..23685831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125247.4 → NP_200668.1  Pmr5/Cas1p GDSL/SGNH-like acyl-esterase family protein (DUF828) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200668.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KGA2, Q8LEB9, Q9LUZ6
      UniProtKB/TrEMBL
      A0A178UAM6, A0A5S9YF67
      Conserved Domains (3) summary
      PLN02629
      Location:1 → 402
      PLN02629; powdery mildew resistance 5
      pfam13839
      Location:119 → 402
      PC-Esterase; GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p
      pfam14416
      Location:65 → 118
      PMR5N; PMR5 N terminal Domain

    2. NM_203232.2 → NP_974961.1  Pmr5/Cas1p GDSL/SGNH-like acyl-esterase family protein (DUF828) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974961.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LUZ6
      Conserved Domains (2) summary
      pfam13839
      Location:119 → 289
      PC-Esterase; GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p
      pfam14416
      Location:65 → 118
      PMR5N; PMR5 N terminal Domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LUZ6.1

    Gene LinkOut

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