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    CNI1 carbon/nitrogen insensitive 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832801, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CNI1
    Official Full Name
    carbon/nitrogen insensitive 1
    Primary source
    TAIR:AT5G27420
    Locus tag
    AT5G27420
    See related
    Araport:AT5G27420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis toxicos en levadura 31; ATL31; carbon/nitrogen insensitive 1; F21A20.130; F21A20_130
    Summary
    Encodes CNI1 (Carbon/Nitrogen Insensitive1) (also named as ATL31), a RING type ubiquitin ligase that functions in the Carbon/Nitrogen response for growth phase transition in Arabidopsis seedlings.
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    Genomic context

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    See CNI1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_003076.8 (9683988..9685742)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene tagatose-6-phosphate ketose/aldose isomerase, putative (Mog1/PsbP/DUF1795-like photosystem II reaction center PsbP family protein) Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein Neighboring gene Signal peptidase subunit Neighboring gene uncharacterized protein Neighboring gene mevalonate kinase Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of senescence under elevated atmospheric CO₂ via ubiquitin modification. Aoyama S, et al. Plant Signal Behav, 2014. PMID 24739470, Free PMC Article
    2. CNI1/ATL31, a RING-type ubiquitin ligase that functions in the carbon/nitrogen response for growth phase transition in Arabidopsis seedlings. Sato T, et al. Plant J, 2009 Dec. PMID 19702666
    3. The Arabidopsis ubiquitin ligases ATL31 and ATL6 regulate plant response to salt stress in an ABA-independent manner. Du M, et al. Biochem Biophys Res Commun, 2023 Dec 10. PMID 37913694
    4. The Agrobacterium F-Box Protein Effector VirF Destabilizes the Arabidopsis GLABROUS1 Enhancer/Binding Protein-Like Transcription Factor VFP4, a Transcriptional Activator of Defense Response Genes. García-Cano E, et al. Mol Plant Microbe Interact, 2018 May. PMID 29264953, Free PMC Article
    5. Ubiquitin ligase ATL31 functions in leaf senescence in response to the balance between atmospheric CO2 and nitrogen availability in Arabidopsis. Aoyama S, et al. Plant Cell Physiol, 2014 Feb. PMID 24399238, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis ubiquitin ligases ATL31 and ATL6 regulate plant response to salt stress in an ABA-independent manner.
      Title: The Arabidopsis ubiquitin ligases ATL31 and ATL6 regulate plant response to salt stress in an ABA-independent manner.
    2. The calcium-dependent protein kinase CPK28 is targeted by the ubiquitin ligases ATL31 and ATL6 for proteasome-mediated degradation to fine-tune immune signaling in Arabidopsis.
      Title: The calcium-dependent protein kinase CPK28 is targeted by the ubiquitin ligases ATL31 and ATL6 for proteasome-mediated degradation to fine-tune immune signaling in Arabidopsis.
    3. Gain-of-function lines of VFP4 and ATL31 exhibited recalcitrance to Agrobacterium tumorigenicity, suggesting that A. tumefaciens may utilize the host ubiquitin/proteasome system to destabilize transcriptional regulators of the host disease response machinery.
      Title: The Agrobacterium F-Box Protein Effector VirF Destabilizes the Arabidopsis GLABROUS1 Enhancer/Binding Protein-Like Transcription Factor VFP4, a Transcriptional Activator of Defense Response Genes.
    4. ATL31 plays an important role in connecting the Carbon/Nitrogen response with basal immunity by promoting papilla formation through its association with SYP121.
      Title: The carbon/nitrogen regulator ARABIDOPSIS TOXICOS EN LEVADURA31 controls papilla formation in response to powdery mildew fungi penetration by interacting with SYNTAXIN OF PLANTS121 in Arabidopsis.
    5. ATL31 plays a role in senescence together with the WRKY53 transcription factor.
      Title: Ubiquitin ligase ATL31 functions in leaf senescence in response to the balance between atmospheric CO2 and nitrogen availability in Arabidopsis.
    6. The physiological role of phosphorylation at 14-3-3 binding sites on ATL31 is to modulate the binding ability and stability of 14-3-3 proteins to control plant C/N-nutrient response.
      Title: Phosphorylation of Arabidopsis ubiquitin ligase ATL31 is critical for plant carbon/nitrogen nutrient balance response and controls the stability of 14-3-3 proteins.
    7. Ubiquitin ligase ATL31 regulates senescence when the CO2/N is disrupted.
      Title: Regulation of senescence under elevated atmospheric CO₂ via ubiquitin modification.
    8. ATL31 targets and ubiquitinates 14-3-3 proteins for degradation via the ubiquitin-proteasome system during the response to cellular C/N status.
      Title: Identification of 14-3-3 proteins as a target of ATL31 ubiquitin ligase, a regulator of the C/N response in Arabidopsis.
    9. Results indicate that ATL31 and ATL6 function as key components of both C/N regulation and the defense response in Arabidopsis.
      Title: The Arabidopsis ubiquitin ligases ATL31 and ATL6 control the defense response as well as the carbon/nitrogen response.
    10. CNI1/ATL31 activity is required for the plant C/N response during seedling growth transition.
      Title: CNI1/ATL31, a RING-type ubiquitin ligase that functions in the carbon/nitrogen response for growth phase transition in Arabidopsis seedlings.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_122624.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within cellular response to nitrogen levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to other organism IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    carbon/nitrogen insensitive 1
    NP_198094.1
    • carbon/nitrogen insensitive 1 (CNI1); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT3G05200.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      9683988..9685742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122624.4 → NP_198094.1  carbon/nitrogen insensitive 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198094.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WUY7, Q8LGA5
      UniProtKB/TrEMBL
      A0A178UL08, A0A654G4U2
      Conserved Domains (1) summary
      cd16461
      Location:123 → 166
      RING-H2_EL5_like; RING finger, H2 subclass, found in rice E3 ubiquitin-protein ligase EL5 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LGA5.2

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