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    UBC2 ubiquiting-conjugating enzyme 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814805, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UBC2
    Official Full Name
    ubiquiting-conjugating enzyme 2
    Primary source
    TAIR:AT2G02760
    Locus tag
    AT2G02760
    See related
    Araport:AT2G02760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATUBC2; T20F6.10; T20F6_10; ubiquitin-conjugating enzyme 2; ubiquiting-conjugating enzyme 2
    Summary
    ubiquitin conjugating enzyme UBC2. Homolog of the yeast RAD6 gene.
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    Genomic context

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    See UBC2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (773645..775902)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ssDNA-binding transcriptional regulator Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Neighboring gene 4'-phosphopantetheinyl transferase domain protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. E2 conjugases UBC1 and UBC2 regulate MYB42-mediated SOS pathway in response to salt stress in Arabidopsis. Sun Y, et al. New Phytol, 2020 Jul. PMID 32167578
    2. Arabidopsis thaliana RAD6 homolog AtUBC2 complements UV sensitivity, but not N-end rule degradation deficiency, of Saccharomyces cerevisiae rad6 mutants. Zwirn P, et al. Curr Genet, 1997 Nov. PMID 9371881
    3. Repression of the floral transition via histone H2B monoubiquitination. Gu X, et al. Plant J, 2009 Feb. PMID 18980658
    4. The E2 ubiquitin-conjugating enzymes, AtUBC1 and AtUBC2, play redundant roles and are involved in activation of FLC expression and repression of flowering in Arabidopsis thaliana. Xu L, et al. Plant J, 2009 Jan. PMID 18798874
    5. Cellular Ubc2/Rad6 E2 ubiquitin-conjugating enzyme facilitates tombusvirus replication in yeast and plants. Imura Y, et al. Virology, 2015 Oct. PMID 26135843

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E2 conjugases UBC1 and UBC2 regulate MYB42-mediated SOS pathway in response to salt stress in Arabidopsis.
      Title: E2 conjugases UBC1 and UBC2 regulate MYB42-mediated SOS pathway in response to salt stress in Arabidopsis.
    2. The authors demonstrate that tombusvirus RNA replication and the mono- and bi-ubiquitination level of p33 is decreased in rad6Delta yeast. However, plasmid-based expression of the Arabidopsis Ubc2p could complement both defects in rad6Delta yeast.
      Title: Cellular Ubc2/Rad6 E2 ubiquitin-conjugating enzyme facilitates tombusvirus replication in yeast and plants.
    3. UBC1 and UBC2 redundantly mediate H2B monoubiquitination, and upregulate the expression of FLC.
      Title: Repression of the floral transition via histone H2B monoubiquitination.
    4. The double mutant Atubc1-1 Atubc2-1 shows a dramatically enhanced mutant phenotype. These two genes act together with HUB1/HUB2 in H2B ubiquitylation, which is involved in the activation of floral repressor genes.
      Title: The E2 ubiquitin-conjugating enzymes, AtUBC1 and AtUBC2, play redundant roles and are involved in activation of FLC expression and repression of flowering in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001335135.1
    NM_001335136.1
    NM_126331.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone H2B deubiquitinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within UV protection IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ubiquiting-conjugating enzyme 2
    NP_565289.1
    • ubiquiting-conjugating enzyme 2 (UBC2); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin carrier protein 1 (TAIR:AT1G14400.2); Has 10642 Blast hits to 10588 proteins in 402 species: Archae - 0; Bacteria - 2; Metazoa - 4556; Fungi - 2331; Plants - 2015; Viruses - 26; Other Eukaryotes - 1712 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      773645..775902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001335134.1 → NP_001325163.1  ubiquiting-conjugating enzyme 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42745, Q4TZ07
      UniProtKB/TrEMBL
      A0A178W0U6, A0A5S9WWP9
      Conserved Domains (1) summary
      cd00195
      Location:7 → 145
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_126331.4 → NP_565289.1  ubiquiting-conjugating enzyme 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565289.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42745, Q4TZ07
      UniProtKB/TrEMBL
      A0A178W0U6, A0A5S9WWP9
      Conserved Domains (1) summary
      cd00195
      Location:7 → 145
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_001335135.1 → NP_001325164.1  ubiquiting-conjugating enzyme 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42745, Q4TZ07
      UniProtKB/TrEMBL
      A0A178W0U6, A0A5S9WWP9
      Conserved Domains (1) summary
      cd00195
      Location:7 → 145
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    4. NM_001335136.1 → NP_001325162.1  ubiquiting-conjugating enzyme 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42745, Q4TZ07
      UniProtKB/TrEMBL
      A0A178W0U6, A0A5S9WWP9
      Conserved Domains (1) summary
      cd00195
      Location:7 → 145
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42745.1

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