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    PROT1 proline transporter 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818576, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PROT1
    Official Full Name
    proline transporter 1
    Primary source
    TAIR:AT2G39890
    Locus tag
    AT2G39890
    See related
    Araport:AT2G39890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPROT1; proline transporter 1; PROLINE TRANSPORTER 1; T28M21.5; T28M21_5
    Summary
    Encodes a proline transporter with affinity for gly betaine, proline and GABA. Protein is expressed in the vascular tissue, specifically the phloem.
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    Genomic context

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    See PROT1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (16655577..16658412)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GATA type zinc finger transcription factor family protein Neighboring gene ARM repeat superfamily protein Neighboring gene HAD superfamily, subfamily IIIB acid phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In planta function of compatible solute transporters of the AtProT family. Lehmann S, et al. J Exp Bot, 2011 Jan. PMID 20959625, Free PMC Article
    2. Salt stress-induced proline transporters and salt stress-repressed broad specificity amino acid permeases identified by suppression of a yeast amino acid permease-targeting mutant. Rentsch D, et al. Plant Cell, 1996 Aug. PMID 8776904, Free PMC Article
    3. The AtProT family. Compatible solute transporters with similar substrate specificity but differential expression patterns. Grallath S, et al. Plant Physiol, 2005 Jan. PMID 15618414, Free PMC Article
    4. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtProT1 and AtProT2 mediate L-proline transport.
      Title: In planta function of compatible solute transporters of the AtProT family.
    2. AtProT1 expression was found in the phloem or phloem parenchyma cells throughout the whole plant, indicative of a role in long-distance transport of compatible solutes.
      Title: The AtProT family. Compatible solute transporters with similar substrate specificity but differential expression patterns.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084556.2
    NM_001336805.1
    NM_129547.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-proline transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proline transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proline transporter 1
    NP_001078025.1
    • proline transporter 1 (PROT1); FUNCTIONS IN: amino acid transmembrane transporter activity, L-proline transmembrane transporter activity; INVOLVED IN: proline transport, amino acid transport; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Amino acid transporter, transmembrane (InterPro:IPR013057); BEST Arabidopsis thaliana protein match is: proline transporter 3 (TAIR:AT2G36590.1); Has 1473 Blast hits to 1467 proteins in 157 species: Archae - 0; Bacteria - 4; Metazoa - 93; Fungi - 146; Plants - 1200; Viruses - 0; Other Eukaryotes - 30 (source: NCBI BLink).
    NP_181518.1
    • proline transporter 1 (PROT1); CONTAINS InterPro DOMAIN/s: Amino acid transporter, transmembrane (InterPro:IPR013057); BEST Arabidopsis thaliana protein match is: proline transporter 3 (TAIR:AT2G36590.1); Has 1473 Blast hits to 1467 proteins in 157 species: Archae - 0; Bacteria - 4; Metazoa - 93; Fungi - 146; Plants - 1200; Viruses - 0; Other Eukaryotes - 30 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16655577..16658412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129547.3 → NP_181518.1  proline transporter 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181518.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04746, P92961, Q8LAE3
      UniProtKB/TrEMBL
      A0A178VQW0, A0A5S9X5M5, A0A654F0E2
      Conserved Domains (1) summary
      pfam01490
      Location:35 → 428
      Aa_trans; Transmembrane amino acid transporter protein

    2. NM_001084556.2 → NP_001078025.1  proline transporter 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078025.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04746, P92961, Q8LAE3
      UniProtKB/TrEMBL
      A0A178VQW0, A0A5S9X5M5, A0A654F0E2
      Conserved Domains (1) summary
      pfam01490
      Location:35 → 428
      Aa_trans; Transmembrane amino acid transporter protein

    3. NM_001336805.1 → NP_001324466.1  proline transporter 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B085, A0A654F0E2, A0A7G2ECL8
      Conserved Domains (1) summary
      cl00456
      Location:1 → 369
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P92961.1

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