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    WTF9 Ubiquitin carboxyl-terminal hydrolase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818498, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WTF9
    Official Full Name
    Ubiquitin carboxyl-terminal hydrolase family protein
    Primary source
    TAIR:AT2G39120
    Locus tag
    AT2G39120
    See related
    Araport:AT2G39120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T7F6.29; T7F6_29; what's this factor 9
    Summary
    Encodes a mitochondrial protein essential for the splicing of group II introns in two mitochondrial genes for which splicing factors had not previously been identified: rpl2 and ccmFc.
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    Genomic context

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    See WTF9 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (16321721..16322957)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat (TPR)-containing protein Neighboring gene RING/U-box superfamily protein Neighboring gene Protein kinase superfamily protein Neighboring gene ncRNA Neighboring gene Transmembrane amino acid transporter family protein Neighboring gene ncRNA Neighboring gene pseudouridine synthase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A PORR domain protein required for rpl2 and ccmF(C) intron splicing and for the biogenesis of c-type cytochromes in Arabidopsis mitochondria. Francs-Small CC, et al. Plant J, 2012 Mar. PMID 22060106
    2. Mitochondrial Heat Shock Protein 60s Interact with What's This Factor 9 to Regulate RNA Splicing of ccmFC and rpl2. Hsu YW, et al. Plant Cell Physiol, 2019 Jan 1. PMID 30289547
    3. In-depth temporal transcriptome profiling reveals a crucial developmental switch with roles for RNA processing and organelle metabolism that are essential for germination in Arabidopsis. Narsai R, et al. Plant Physiol, 2011 Nov. PMID 21908688, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HSP60s interacted with WTF9, which was further confirmed by a pull-down assay.
      Title: Mitochondrial Heat Shock Protein 60s Interact with What's This Factor 9 to Regulate RNA Splicing of ccmFC and rpl2.
    2. WTF9 is essential for the splicing of group II introns in two mitochondrial genes rpl2 and ccmF(C). Loss of ccmF(C) expression correlates with the loss of cytochromes c and c, confirming a role for ccmF(C) in cytochrome biogenesis. [WTF9]
      Title: A PORR domain protein required for rpl2 and ccmF(C) intron splicing and for the biogenesis of c-type cytochromes in Arabidopsis mitochondria.
    3. WTF9 is required for normal plant growth and development.
      Title: A PORR domain protein required for rpl2 and ccmF(C) intron splicing and for the biogenesis of c-type cytochromes in Arabidopsis mitochondria.
    Submit: New GeneRIF Correction

    General gene information

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    NM_129469.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Group II intron splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytochrome complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ubiquitin carboxyl-terminal hydrolase family protein
    NP_181445.1
    • Ubiquitin carboxyl-terminal hydrolase family protein; LOCATED IN: mitochondrion; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition domain, plant (InterPro:IPR021099); BEST Arabidopsis thaliana protein match is: Ubiquitin carboxyl-terminal hydrolase family protein (TAIR:AT3G58520.1); Has 404 Blast hits to 398 proteins in 16 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 404; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16321721..16322957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129469.2 → NP_181445.1  Ubiquitin carboxyl-terminal hydrolase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181445.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZUZ6
      UniProtKB/TrEMBL
      A0A178VL86, A0A5S9X5A6
      Conserved Domains (1) summary
      pfam11955
      Location:32 → 360
      PORR; Plant organelle RNA recognition domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZUZ6.1

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