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    MGP C2H2 and C2HC zinc fingers superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839396, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MGP
    Official Full Name
    C2H2 and C2HC zinc fingers superfamily protein
    Primary source
    TAIR:AT1G03840
    Locus tag
    AT1G03840
    See related
    Araport:AT1G03840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F21M11.25; F21M11_25; IDD3; INDETERMINATE DOMAIN 3; Magpie
    Summary
    MGP is a nuclear-localized putative transcription factor with three zinc finger domains. MGP can interact with three proteins implicated in root patterning: SCR, SHR, and JKD in Y2H assays, and these interactions depend on the first zinc finger in MGP. MGP appears to be a direct transcriptional target of SHR and SCR, based on promoter binding assays, though it is not expressed in the QC, based on in situ hybridizations.
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    Genomic context

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    See MGP in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (967470..970334, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene E6-like protein Neighboring gene guanylate-binding family protein Neighboring gene Glutaredoxin family protein Neighboring gene prohibitin 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis BIRD Zinc Finger Proteins Jointly Stabilize Tissue Boundaries by Confining the Cell Fate Regulator SHORT-ROOT and Contributing to Fate Specification. Long Y, et al. Plant Cell, 2015 Apr. PMID 25829440, Free PMC Article
    2. Activity of transcription factor JACKDAW is essential for SHR/SCR-dependent activation of SCARECROW and MAGPIE and is modulated by reciprocal interactions with MAGPIE, SCARECROW and SHORT ROOT. Ogasawara H, et al. Plant Mol Biol, 2011 Nov. PMID 21935722
    3. Transcriptional control of tissue formation throughout root development. Moreno-Risueno MA, et al. Science, 2015 Oct 23. PMID 26494755, Free PMC Article
    4. Arabidopsis JACKDAW and MAGPIE zinc finger proteins delimit asymmetric cell division and stabilize tissue boundaries by restricting SHORT-ROOT action. Welch D, et al. Genes Dev, 2007 Sep 1. PMID 17785527, Free PMC Article
    5. DELLA protein functions as a transcriptional activator through the DNA binding of the indeterminate domain family proteins. Yoshida H, et al. Proc Natl Acad Sci U S A, 2014 May 27. PMID 24821766, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. JKD directly regulates SCR and MGP expression in cooperation with SHR, SCR and MGP.
      Title: Activity of transcription factor JACKDAW is essential for SHR/SCR-dependent activation of SCARECROW and MAGPIE and is modulated by reciprocal interactions with MAGPIE, SCARECROW and SHORT ROOT.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001035874.1
    NM_100263.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of gibberellic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of meristem growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    C2H2 and C2HC zinc fingers superfamily protein
    NP_001030951.1
    • Magpie (MGP); CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-like (InterPro:IPR015880), Zinc finger, C2H2-type (InterPro:IPR007087); BEST Arabidopsis thaliana protein match is: C2H2-like zinc finger protein (TAIR:AT5G44160.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_171880.1
    • Magpie (MGP); CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-type (InterPro:IPR007087); BEST Arabidopsis thaliana protein match is: C2H2-like zinc finger protein (TAIR:AT5G44160.1); Has 50307 Blast hits to 19551 proteins in 373 species: Archae - 0; Bacteria - 2; Metazoa - 47709; Fungi - 273; Plants - 826; Viruses - 4; Other Eukaryotes - 1493 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      967470..970334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100263.4 → NP_171880.1  C2H2 and C2HC zinc fingers superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171880.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q700E8, Q9ZWA6
      UniProtKB/TrEMBL
      A0A178W8W7, A0A384LMU1, A0A7G2DR01, C0SUS5
      Conserved Domains (1) summary
      sd00017
      Location:72 → 92
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001035874.1 → NP_001030951.1  C2H2 and C2HC zinc fingers superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030951.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2DR01
      Conserved Domains (1) summary
      sd00017
      Location:70 → 90
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZWA6.1

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