CIPK9 CBL-interacting protein kinase 9 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CIPK9
Official Full Name: CBL-interacting protein kinase 9
Primary source: TAIR:AT1G01140
Locus tag: AT1G01140
See related: Araport:AT1G01140
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: CBL-interacting protein kinase 9; F6F3.28; PKS6; PROTEIN KINASE 6; SNF1-RELATED PROTEIN KINASE 3.12; SnRK3.12
Summary: Encodes a CBL-interacting protein kinase with similarity to SOS2
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Genomic context

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See CIPK9 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 14

Sequence:: Chromosome: 1; NC_003070.9 (64166..67774, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CIPK9 targets VDAC3 and modulates oxidative stress responses in Arabidopsis.
Title: CIPK9 targets VDAC3 and modulates oxidative stress responses in Arabidopsis.
Arabidopsis K+ transporter HAK5-mediated high-affinity root K+ uptake is regulated by protein kinases CIPK1 and CIPK9.
Title: Arabidopsis K+ transporter HAK5-mediated high-affinity root K+ uptake is regulated by protein kinases CIPK1 and CIPK9.
study shows that AP2C1 and CIPK9 interact to regulate K+-deficiency responses in Arabidopsis. CIPK9 functions as positive regulator whereas AP2C1 acts as a negative regulator of Arabidopsis root growth and seedling development under low-K+ conditions
Title: A protein phosphatase 2C, AP2C1, interacts with and negatively regulates the function of CIPK9 under potassium-deficient conditions in Arabidopsis.
study suggests that CIPK9 differentially phosphorylates interacting CBLs, and furthermore, the kinase activity of CIPK9 is also differentially regulated by specific interacting CBLs.
Title: Arabidopsis calcineurin B-like proteins differentially regulate phosphorylation activity of CBL-interacting protein kinase 9.
CBL3 and CIPK9 regulates potassium homeostasis under low potassium stress.
Title: A protein kinase, calcineurin B-like protein-interacting protein Kinase9, interacts with calcium sensor calcineurin B-like Protein3 and regulates potassium homeostasis under low-potassium stress in Arabidopsis.
CIPK9 gene was responsive to abiotic stress conditions, and its transcript was inducible in both roots and shoots by potassium deprivation. Disruption of CIPK9 function rendered the mutant plants hypersensitive to low potassium media.
Title: CIPK9: a calcium sensor-interacting protein kinase required for low-potassium tolerance in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_099996.4

Supported by ESTs:

NM_179239.1

Supported by ESTs:

NM_179240.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to potassium ion starvation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within potassium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to mannitol	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to wounding	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CBL-interacting protein kinase 9

NP_171622.1

CBL-interacting protein kinase 9 (CIPK9); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: in 6 processes; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), CBL-interacting protein kinase (InterPro:IPR020660), NAF domain (InterPro:IPR004041), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: CBL-interacting protein kinase 23 (TAIR:AT1G30270.1); Has 130203 Blast hits to 128118 proteins in 4349 species: Archae - 165; Bacteria - 15262; Metazoa - 47961; Fungi - 13206; Plants - 31482; Viruses - 522; Other Eukaryotes - 21605 (source: NCBI BLink).

NP_849570.1

CBL-interacting protein kinase 9 (CIPK9); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: in 6 processes; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), NAF domain (InterPro:IPR004041), CBL-interacting protein kinase (InterPro:IPR020660), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: CBL-interacting protein kinase 23 (TAIR:AT1G30270.1); Has 130491 Blast hits to 128500 proteins in 4421 species: Archae - 165; Bacteria - 15543; Metazoa - 48035; Fungi - 13165; Plants - 31462; Viruses - 522; Other Eukaryotes - 21599 (source: NCBI BLink).

NP_849571.1

CBL-interacting protein kinase 9 (CIPK9); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: in 6 processes; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), NAF domain (InterPro:IPR004041), CBL-interacting protein kinase (InterPro:IPR020660), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: CBL-interacting protein kinase 23 (TAIR:AT1G30270.1); Has 130572 Blast hits to 128490 proteins in 4426 species: Archae - 165; Bacteria - 15544; Metazoa - 48044; Fungi - 13206; Plants - 31490; Viruses - 522; Other Eukaryotes - 21601 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

64166..67774 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_099996.4 → NP_171622.1 CBL-interacting protein kinase 9 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_171622.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q3EDL5, Q94F03, Q9C5P5, Q9C5S4, Q9MAM1

UniProtKB/TrEMBL

A0A178W7T6, A0A7G2DPR6

Conserved Domains (2) summary

cd12195
Location:318 → 433

CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases

cd14663
Location:19 → 273

STKc_SnRK3; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3
NM_179240.1 → NP_849571.1 CBL-interacting protein kinase 9 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849571.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2DPR6

Conserved Domains (3) summary

cd12195
Location:318 → 437

CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases

smart00220
Location:19 → 274

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14663
Location:19 → 273

STKc_SnRK3; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3
NM_179239.1 → NP_849570.1 CBL-interacting protein kinase 9 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849570.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2DPR6

Conserved Domains (3) summary

cd12195
Location:320 → 435

CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases

smart00220
Location:19 → 276

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14663
Location:19 → 275

STKc_SnRK3; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3