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    FBP Inositol monophosphatase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840953, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FBP
    Official Full Name
    Inositol monophosphatase family protein
    Primary source
    TAIR:AT1G43670
    Locus tag
    AT1G43670
    See related
    Araport:AT1G43670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    6-bisphosphatase; Arabidopsis thaliana cytosolic fructose-1; AtcFBP; F2J6.2; F2J6_2; FINS1; FRUCTOSE INSENSITIVE 1; fructose-1
    Summary
    Encodes a fructose-1,6-bisphosphatase. This enzyme, in addition to catalyzing the formation of fructose-6-phosphate for sucrose biosynthesis, appears to play a role in fructose-mediated signaling that is independent of its enzymatic activity. atcfbp-1/fins1 mutants have reduced photosynthetic rates, elevated levels of starch and reduced levels of sucrose during the day. Although the protein is expected to be cytosolic, a GFP-tagged version localizes to the cytoplasm and the nucleus.
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    Genomic context

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    See FBP in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (16467298..16470500)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FRUCTOSE INSENSITIVE1 regulates stem cell function in Arabidopsis in response to fructose signalling. Li Y, et al. J Exp Bot, 2023 May 19. PMID 36806617
    2. A FIT-binding protein is involved in modulating iron and zinc homeostasis in Arabidopsis. Chen CL, et al. Plant Cell Environ, 2018 Jul. PMID 29677391
    3. Loss of cytosolic fructose-1,6-bisphosphatase limits photosynthetic sucrose synthesis and causes severe growth retardations in rice (Oryza sativa). Lee SK, et al. Plant Cell Environ, 2008 Dec. PMID 18811733
    4. Decreased expression of two key enzymes in the sucrose biosynthesis pathway, cytosolic fructose-1,6-bisphosphatase and sucrose phosphate synthase, has remarkably different consequences for photosynthetic carbon metabolism in transgenic Arabidopsis thaliana. Strand A, et al. Plant J, 2000 Sep. PMID 10998187
    5. Signaling role of fructose mediated by FINS1/FBP in Arabidopsis thaliana. Cho YH, et al. PLoS Genet, 2011 Jan 6. PMID 21253566, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FRUCTOSE INSENSITIVE1 regulates stem cell function in Arabidopsis in response to fructose signalling.
      Title: FRUCTOSE INSENSITIVE1 regulates stem cell function in Arabidopsis in response to fructose signalling.
    2. involved in modulating iron and zinc homeostasis
      Title: A FIT-binding protein is involved in modulating iron and zinc homeostasis in Arabidopsis.
    3. FRUCTOSE INSENSITIVE 1 is an indispensable regulatory factor in the signaling pathway; its function in fructose signaling appears to be independent of its catalytic activity in sugar metabolism. [FRUCTOSE INSENSITIVE 1] [FINS1]
      Title: Signaling role of fructose mediated by FINS1/FBP in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_103492.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables fructose 1,6-bisphosphate 1-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within fructose 1,6-bisphosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within photosynthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fructose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within starch catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sucrose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Inositol monophosphatase family protein
    NP_175032.1
    • Inositol monophosphatase family protein; FUNCTIONS IN: fructose 1,6-bisphosphate 1-phosphatase activity, phosphoric ester hydrolase activity; INVOLVED IN: carbohydrate metabolic process, fructose metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Fructose-1,6-bisphosphatase, active site (InterPro:IPR020548), Fructose-1,6-bisphosphatase (InterPro:IPR000146); BEST Arabidopsis thaliana protein match is: high cyclic electron flow 1 (TAIR:AT3G54050.2); Has 3746 Blast hits to 3738 proteins in 1274 species: Archae - 47; Bacteria - 2330; Metazoa - 401; Fungi - 156; Plants - 330; Viruses - 0; Other Eukaryotes - 482 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      16467298..16470500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103492.5 → NP_175032.1  Inositol monophosphatase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175032.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9MA79
      UniProtKB/TrEMBL
      A0A178WCE5, A0A5S9WJX9, A0A7G2DYE2
      Conserved Domains (1) summary
      PLN02262
      Location:1 → 340
      PLN02262; fructose-1,6-bisphosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9MA79.1

    Gene LinkOut

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