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    GCT RNA polymerase II transcription mediator [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841978, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GCT
    Official Full Name
    RNA polymerase II transcription mediator
    Primary source
    TAIR:AT1G55325
    Locus tag
    AT1G55325
    See related
    Araport:AT1G55325
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CCT; CENTER CITY; GRAND CENTRAL; MAB2; MACCHI-BOU 2
    Summary
    Encodes the Arabidopsis homolog of the transcriptional regulator MED13, is dynamically expressed during embryogenesis and regulates both developmental timing and the radial pattern formation.
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    Genomic context

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    See GCT in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    26
    Sequence:
    Chromosome: 1; NC_003070.9 (20637333..20648434)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene SC35-like splicing factor 33 Neighboring gene acyl-activating enzyme 18 Neighboring gene uncharacterized protein Neighboring gene arabinogalactan protein 21 Neighboring gene hypothetical protein (DUF1639) Neighboring gene calpain-type cysteine protease family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss-of-function of MEDIATOR 12 or 13 subunits causes the swelling of root hairs in response to sucrose and abscisic acid in Arabidopsis. Raya-González J, et al. Plant Signal Behav, 2023 Dec 31. PMID 36942634, Free PMC Article
    2. The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis. Liu Q, et al. Nat Commun, 2020 Jun 3. PMID 32493925, Free PMC Article
    3. The MEDIATOR genes MED12 and MED13 control Arabidopsis root system configuration influencing sugar and auxin responses. Raya-González J, et al. Plant Mol Biol, 2017 Sep. PMID 28780645
    4. The Arabidopsis Mediator CDK8 module genes CCT (MED12) and GCT (MED13) are global regulators of developmental phase transitions. Gillmor CS, et al. Development, 2014 Dec. PMID 25377553, Free PMC Article
    5. The MED12-MED13 module of Mediator regulates the timing of embryo patterning in Arabidopsis. Gillmor CS, et al. Development, 2010 Jan. PMID 20023166, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss-of-function of MEDIATOR 12 or 13 subunits causes the swelling of root hairs in response to sucrose and abscisic acid in Arabidopsis.
      Title: Loss-of-function of MEDIATOR 12 or 13 subunits causes the swelling of root hairs in response to sucrose and abscisic acid in Arabidopsis.
    2. MED12/13 is required to facilitate the expression of genes making the transition from silent to active states. [MED13]
      Title: The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis.
    3. med12 and med13 single mutants exhibit shoot and root phenotypes consistent with altered auxin homeostasis including altered primary root growth, lateral root development, and root hair elongation.[MED13]
      Title: The MEDIATOR genes MED12 and MED13 control Arabidopsis root system configuration influencing sugar and auxin responses.
    4. The results suggest that HSI2 recruits MED13 and HDA6 to suppress directly a subset of seed maturation genes post-germination.
      Title: HSI2 Repressor Recruits MED13 and HDA6 to Down-Regulate Seed Maturation Gene Expression Directly During Arabidopsis Early Seedling Growth.
    5. GCT and CCT coordinate vegetative and floral transitions by repressing the repressors miR156 and FLC.
      Title: The Arabidopsis Mediator CDK8 module genes CCT (MED12) and GCT (MED13) are global regulators of developmental phase transitions.
    6. MAB2 plays a crucial role in embryo patterning and cotyledon organogenesis. [MAB2] [MACCHI-BOU 2]
      Title: MACCHI-BOU 2 is required for early embryo patterning and cotyledon organogenesis in Arabidopsis.
    7. MED13 and MED12 regulate pattern formation during Arabidopsis embryogenesis by transiently repressing a transcriptional program that interferes with this process [MED13]
      Title: The MED12-MED13 module of Mediator regulates the timing of embryo patterning in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_179478.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of development, heterochronic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of radial pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase II transcription mediator
    NP_001185237.1
    • GRAND CENTRAL (GCT); FUNCTIONS IN: RNA polymerase II transcription mediator activity; INVOLVED IN: regulation of development, heterochronic, regulation of radial pattern formation; LOCATED IN: mediator complex; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Mediator complex, subunit Med13 (InterPro:IPR009401).
    NP_849809.2
    • GRAND CENTRAL (GCT); INVOLVED IN: regulation of development, heterochronic, regulation of radial pattern formation; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20637333..20648434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333703.1 → NP_001322789.1  RNA polymerase II transcription mediator [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WE89, A0A1P8AV32

    2. NM_001333704.1 → NP_001322788.1  RNA polymerase II transcription mediator [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WE89, A0A1P8AV32

    3. NM_001198308.1 → NP_001185237.1  RNA polymerase II transcription mediator [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185237.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WRW3
      Conserved Domains (1) summary
      pfam06333
      Location:1221 → 1585
      Med13_C; Mediator complex subunit 13 C-terminal

    4. NM_179478.2 → NP_849809.2  RNA polymerase II transcription mediator [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849809.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I095, F4I096
      UniProtKB/TrEMBL
      A0A178WE89
      Conserved Domains (1) summary
      pfam06333
      Location:1265 → 1382
      Med13_C; Mediator complex subunit 13 C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4I096.1

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