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    HAC5 histone acetyltransferase of the CBP family 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820484, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HAC5
    Official Full Name
    histone acetyltransferase of the CBP family 5
    Primary source
    TAIR:AT3G12980
    Locus tag
    AT3G12980
    See related
    Araport:AT3G12980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATHPCAT4; histone acetyltransferase of the CBP family 5; HISTONE ACETYLTRANSFERASE OF THE CBP FAMILY 5; MGH6.20
    Summary
    Encodes an enzyme with histone acetyltransferase activity that can use both H3 and H4 histones as substrates. No single prior lysine acetylation is sufficient to block HAC5 acetylation of the H3 or H4 peptides, suggesting that HAC5 can acetylate any of several lysines present in the peptides. Di-acetylation of both lysines 9 and 14 on the H3 peptide significantly reduces the level of incorporated radioactive acetylation catalyzed by HAC5, indicating that HAC5 may acetylate either lysine 9 or lysine 14.
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    Genomic context

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    See HAC5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    17
    Sequence:
    Chromosome: 3; NC_003074.8 (4146399..4154895)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix-like protein Neighboring gene NAC (No Apical Meristem) domain transcriptional regulator superfamily protein Neighboring gene miscRNA Neighboring gene ribonuclease PH45A Neighboring gene ubiquinone biosynthesis protein (Protein of unknown function, DUF547)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of plant CBP/p300-like genes in the regulation of flowering time. Han SK, et al. Plant J, 2007 Jan. PMID 17144897
    2. The CBP/p300 histone acetyltransferases function as plant-specific MEDIATOR subunits in Arabidopsis. Guo J, et al. J Integr Plant Biol, 2021 Apr. PMID 33325122
    3. In vitro specificities of Arabidopsis co-activator histone acetyltransferases: implications for histone hyperacetylation in gene activation. Earley KW, et al. Plant J, 2007 Nov. PMID 17877703
    4. Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes. Pandey R, et al. Nucleic Acids Res, 2002 Dec 1. PMID 12466527, Free PMC Article
    5. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001338016.1
    NM_112135.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within flower development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein acetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mediator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    histone acetyltransferase of the CBP family 5
    NP_187904.1
    • histone acetyltransferase of the CBP family 5 (HAC5); FUNCTIONS IN: histone acetyltransferase activity; INVOLVED IN: flower development, protein amino acid acetylation; LOCATED IN: nucleus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Histone H3-K56 acetyltransferase, RTT109 (InterPro:IPR013178), Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, TAZ-type (InterPro:IPR000197), Zinc finger, PHD-type (InterPro:IPR001965), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, ZZ-type (InterPro:IPR000433); BEST Arabidopsis thaliana protein match is: histone acetyltransferase of the CBP family 1 (TAIR:AT1G79000.1); Has 1382 Blast hits to 1050 proteins in 154 species: Archae - 0; Bacteria - 14; Metazoa - 567; Fungi - 56; Plants - 349; Viruses - 4; Other Eukaryotes - 392 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      4146399..4154895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112135.4 → NP_187904.1  histone acetyltransferase of the CBP family 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187904.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LRK5, Q8LRK6, Q9LE42
      UniProtKB/TrEMBL
      A0A5S9XBM2, A0A654F6L1, A0A7G2EPQ0
      Conserved Domains (4) summary
      smart00551
      Location:612 → 690
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd15614
      Location:973 → 1043
      PHD_HAC_like; PHD finger found in Arabidopsis thaliana histone acetyltransferases (HATs) HAC and similar proteins
      cl00295
      Location:1504 → 1540
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
      cl02120
      Location:1103 → 1323
      HAT_KAT11; Histone acetylation protein

    2. NM_001338016.1 → NP_001326496.1  histone acetyltransferase of the CBP family 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LPG3, A0A7G2EPQ0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LE42.1

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