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    AZG1 AZA-guanine resistant1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820267, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AZG1
    Official Full Name
    AZA-guanine resistant1
    Primary source
    TAIR:AT3G10960
    Locus tag
    AT3G10960
    See related
    Araport:AT3G10960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATAZG1; AZA-guanine resistant1
    Summary
    Encodes a homolog of the adenine-guanine-hypoxanthine transporter AzgA of Aspergillus nidulans. Function as a plant adenine-guanine transporter. Two closely related genes exist in Arabidopsis: AT3G10960 (Azg1) and AT5G50300 (Azg2).
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    Genomic context

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    See AZG1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (3424813..3427058, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene dual specificity protein phosphatase (DsPTP1) family protein Neighboring gene Zinc-binding ribosomal protein family protein Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structures and mechanisms of the Arabidopsis cytokinin transporter AZG1. Xu L, et al. Nat Plants, 2024 Jan. PMID 38172575
    2. AZG1 is a cytokinin transporter that interacts with auxin transporter PIN1 and regulates the root stress response. Tessi TM, et al. New Phytol, 2023 Jun. PMID 36918499
    3. AtAzg1 and AtAzg2 comprise a novel family of purine transporters in Arabidopsis. Mansfield TA, et al. FEBS Lett, 2009 Jan 22. PMID 19121308
    4. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article
    5. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structures and mechanisms of the Arabidopsis cytokinin transporter AZG1.
      Title: Structures and mechanisms of the Arabidopsis cytokinin transporter AZG1.
    2. AZG1 is a cytokinin transporter that interacts with auxin transporter PIN1 and regulates the root stress response.
      Title: AZG1 is a cytokinin transporter that interacts with auxin transporter PIN1 and regulates the root stress response.
    3. AtAzg1 acts as adenine-guanine transporter.
      Title: AtAzg1 and AtAzg2 comprise a novel family of purine transporters in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_111933.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables purine nucleobase transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in guanine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within purine nucleobase transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    AZA-guanine resistant1
    NP_566384.1
    • AZA-guanine resistant1 (AZG1); FUNCTIONS IN: transmembrane transporter activity, purine transmembrane transporter activity; INVOLVED IN: purine transport; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Xanthine/uracil/vitamin C permease (InterPro:IPR006043); BEST Arabidopsis thaliana protein match is: Xanthine/uracil permease family protein (TAIR:AT5G50300.1); Has 8325 Blast hits to 8321 proteins in 1933 species: Archae - 105; Bacteria - 6300; Metazoa - 12; Fungi - 117; Plants - 83; Viruses - 0; Other Eukaryotes - 1708 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3424813..3427058 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111933.3 → NP_566384.1  AZA-guanine resistant1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566384.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WUT2, Q8LDL2, Q9SRK7
      UniProtKB/TrEMBL
      A0A178VPT2, A0A5S9XBK0, A0A654F5Z8
      Conserved Domains (1) summary
      COG2252
      Location:29 → 542
      AzgA; Xanthine/uracil/vitamin C permease, AzgA family [Nucleotide transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SRK7.1

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