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    SAUL1 senescence-associated E3 ubiquitin ligase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838668, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SAUL1
    Official Full Name
    senescence-associated E3 ubiquitin ligase 1
    Primary source
    TAIR:AT1G20780
    Locus tag
    AT1G20780
    See related
    Araport:AT1G20780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA PLANT U-BOX 44; ATPUB44; F2D10.27; F2D10_27; PLANT U-BOX 44; PUB44; senescence-associated E3 ubiquitin ligase 1
    Summary
    Encodes a protein containing a U-box and an ARM domain. Homozygous mutant seedlings have a seedling lethal phenotype with widespread cell death lesions throughout the cotyledons and roots.
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    Genomic context

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    See SAUL1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (7217021..7220842)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Calcium-binding EF hand family protein Neighboring gene coiled-coil protein Neighboring gene F-box family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis PLANT U-BOX44 down-regulates osmotic stress signaling by mediating Ca2+-DEPENDENT PROTEIN KINASE4 degradation. Fan W, et al. Plant Cell, 2023 Sep 27. PMID 37338064, Free PMC Article
    2. Structural Features of a Full-Length Ubiquitin Ligase Responsible for the Formation of Patches at the Plasma Membrane. Knop J, et al. Int J Mol Sci, 2021 Aug 31. PMID 34502365, Free PMC Article
    3. NORE1/SAUL1 integrates temperature-dependent defense programs involving SGT1b and PAD4 pathways and leaf senescence in Arabidopsis. Lee IH, et al. Physiol Plant, 2016 Oct. PMID 26910207
    4. Membrane-Associated Ubiquitin Ligase SAUL1 Suppresses Temperature- and Humidity-Dependent Autoimmunity in Arabidopsis. Disch EM, et al. Mol Plant Microbe Interact, 2016 Jan. PMID 26505534
    5. Altered germination and subcellular localization patterns for PUB44/SAUL1 in response to stress and phytohormone treatments. Salt JN, et al. PLoS One, 2011. PMID 21738636, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural Features of a Full-Length Ubiquitin Ligase Responsible for the Formation of Patches at the Plasma Membrane.
      Title: Structural Features of a Full-Length Ubiquitin Ligase Responsible for the Formation of Patches at the Plasma Membrane.
    2. The novel protein CSAP accelerates leaf senescence and is negatively regulated by SAUL1 in the dark.
      Title: The novel protein CSAP accelerates leaf senescence and is negatively regulated by SAUL1 in the dark.
    3. differential pairings of typical Toll Interleukin1 receptor (TIR) type NLR (TNL) receptor SOC3 with atypical truncated TIR-NB (TN) proteins CHS1 or TN2 to guard the homeostasis of the E3 ligase SAUL1, are reported.
      Title: TIR-NB-LRR immune receptor SOC3 pairs with truncated TIR-NB protein CHS1 or TN2 to monitor the homeostasis of E3 ligase SAUL1.
    4. the E3 ligase SAUL1 serves as a positive regulator of PAMP-triggered immunity and its homeostasis is monitored by the SOC3.
      Title: E3 ligase SAUL1 serves as a positive regulator of PAMP-triggered immunity and its homeostasis is monitored by immune receptor SOC3.
    5. NORE1/SAUL1 is a key factor integrating signals from temperature-dependent defense programs and leaf senescence in Arabidopsis.
      Title: NORE1/SAUL1 integrates temperature-dependent defense programs involving SGT1b and PAD4 pathways and leaf senescence in Arabidopsis.
    6. This study showed that Arabidopsis with a mutation of SAUL1 exhibit characteristics of an autoimmune mutant.
      Title: Membrane-Associated Ubiquitin Ligase SAUL1 Suppresses Temperature- and Humidity-Dependent Autoimmunity in Arabidopsis.
    7. saul1 senescence depends on the PAD4-dependent salicylic acid pathway but does not require NPR1 signaling.
      Title: Early senescence and cell death in Arabidopsis saul1 mutants involves the PAD4-dependent salicylic acid pathway.
    8. The Arabidopsis PUB43 and PUB44 genes are proposed to function during seed germination and early seedling growth.
      Title: Altered germination and subcellular localization patterns for PUB44/SAUL1 in response to stress and phytohormone treatments.
    9. C-terminal armadillo repeats are essential for SAUL1 localizes to the plasma membrane.
      Title: C-terminal armadillo repeats are essential and sufficient for association of the plant U-box armadillo E3 ubiquitin ligase SAUL1 with the plasma membrane.
    10. SAUL1 represents a regulatory element that prevents senescence from occurring prematurely by targeting AAO3 for degradation.
      Title: Identification of a novel E3 ubiquitin ligase that is required for suppression of premature senescence in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001332465.1
    NM_001332466.1
    NM_101930.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane receptor protein serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of abscisic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of abscisic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of chlorophyll biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of chlorophyll catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to osmotic stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    senescence-associated E3 ubiquitin ligase 1
    NP_564125.2
    • senescence-associated E3 ubiquitin ligase 1 (SAUL1); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: regulation of chlorophyll catabolic process, regulation of chlorophyll biosynthetic process, leaf senescence, regulation of abscisic acid biosynthetic process; LOCATED IN: plasma membrane; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: U box domain (InterPro:IPR003613), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: ARM repeat superfamily protein (TAIR:AT1G76390.2); Has 2790 Blast hits to 2660 proteins in 201 species: Archae - 0; Bacteria - 20; Metazoa - 434; Fungi - 161; Plants - 1969; Viruses - 3; Other Eukaryotes - 203 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      7217021..7220842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101930.4 → NP_564125.2  senescence-associated E3 ubiquitin ligase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564125.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93YT4, Q9LM76
      UniProtKB/TrEMBL
      A0A178W875, A0A5S9VDD9
      Conserved Domains (4) summary
      smart00504
      Location:26 → 94
      Ubox; Modified RING finger domain
      PLN03200
      Location:137 → 387
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00044
      Location:273 → 298
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:137 → 173
      ARM; armadillo repeat [structural motif]

    2. NM_001332465.1 → NP_001323170.1  senescence-associated E3 ubiquitin ligase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93YT4, Q9LM76
      UniProtKB/TrEMBL
      A0A178W875, A0A5S9VDD9
      Conserved Domains (4) summary
      smart00504
      Location:26 → 94
      Ubox; Modified RING finger domain
      PLN03200
      Location:137 → 387
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00044
      Location:273 → 298
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:137 → 173
      ARM; armadillo repeat [structural motif]

    3. NM_001332466.1 → NP_001323169.1  senescence-associated E3 ubiquitin ligase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93YT4, Q9LM76
      UniProtKB/TrEMBL
      A0A178W875, A0A5S9VDD9
      Conserved Domains (4) summary
      smart00504
      Location:26 → 94
      Ubox; Modified RING finger domain
      PLN03200
      Location:137 → 387
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00044
      Location:273 → 298
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:137 → 173
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LM76.1

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