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    KCO6 Ca2+ activated outward rectifying K+ channel 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827541, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KCO6
    Official Full Name
    Ca2+ activated outward rectifying K+ channel 6
    Primary source
    TAIR:AT4G18160
    Locus tag
    AT4G18160
    See related
    Araport:AT4G18160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATKCO6; ATTPK3; Ca2+ activated outward rectifying K+ channel 6; CA2+ ACTIVATED OUTWARD RECTIFYING K+ CHANNEL 6; F15J5.130; F15J5_130; TPK3
    Summary
    Encodes AtTPK3 (KCO6), a member of the Arabidopsis thaliana K+ channel family of AtTPK/KCO proteins.AtTPK3 is targeted to the vacuolar membrane. May form homomeric ion channels in vivo.
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    Genomic context

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    See KCO6 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_003075.7 (10055379..10058185)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene phytochrome E Neighboring gene SCP1-like small phosphatase 4b Neighboring gene Serine/Threonine-kinase, putative (DUF1296) Neighboring gene WRKY DNA-binding protein 28 Neighboring gene Pectin lyase-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A thylakoid-located two-pore K+ channel controls photosynthetic light utilization in plants. Carraretto L, et al. Science, 2013 Oct 4. PMID 24009357
    2. Arabidopsis thaliana vacuolar TPK channels form functional K⁺ uptake pathways in Escherichia coli. Isayenkov S, et al. Plant Signal Behav, 2013 Jul. PMID 23656881, Free PMC Article
    3. Voltage-dependent gating of SV channel TPC1 confers vacuole excitability. Jaślan D, et al. Nat Commun, 2019 Jun 14. PMID 31201323, Free PMC Article
    4. Photosynthesis in Arabidopsis Is Unaffected by the Function of the Vacuolar K(+) Channel TPK3. Höhner R, et al. Plant Physiol, 2019 Jul. PMID 31053658, Free PMC Article
    5. Members of the Arabidopsis AtTPK/KCO family form homomeric vacuolar channels in planta. Voelker C, et al. Plant J, 2006 Oct. PMID 16984403

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Photosynthesis in Arabidopsis Is Unaffected by the Function of the Vacuolar K(+) Channel TPK3.
      Title: Photosynthesis in Arabidopsis Is Unaffected by the Function of the Vacuolar K(+) Channel TPK3.
    2. KCO6 does not form functional potassium channels when expressed in E. coli
      Title: Arabidopsis thaliana vacuolar TPK channels form functional K⁺ uptake pathways in Escherichia coli.
    3. the TPK3 channel manages the proton motive force necessary to convert photochemical energy into physiological functions.
      Title: A thylakoid-located two-pore K+ channel controls photosynthetic light utilization in plants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_117926.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to electrical stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within nonphotochemical quenching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT acts_upstream_of_or_within photosynthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within thylakoid membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast stromal thylakoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of potassium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ca2+ activated outward rectifying K+ channel 6
    NP_193550.1
    • Ca2+ activated outward rectifying K+ channel 6 (KCO6); FUNCTIONS IN: outward rectifier potassium channel activity; INVOLVED IN: potassium ion transport; LOCATED IN: plant-type vacuole membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Potassium channel, two pore-domain (InterPro:IPR003280), EF-Hand 1, calcium-binding site (InterPro:IPR018247), Ion transport 2 (InterPro:IPR013099); BEST Arabidopsis thaliana protein match is: Ca2+ activated outward rectifying K+ channel 2 (TAIR:AT5G46370.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10055379..10058185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117926.3 → NP_193550.1  Ca2+ activated outward rectifying K+ channel 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193550.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SVV6
      UniProtKB/TrEMBL
      A0A178UWR8, A0A5S9XTU0, A0A7G2F3I8
      Conserved Domains (2) summary
      pfam07885
      Location:156 → 237
      Ion_trans_2; Ion channel
      pfam13499
      Location:374 → 431
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SVV6.1

    Gene LinkOut

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