SAE1A SUMO-activating enzyme 1A [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SAE1A
Official Full Name: SUMO-activating enzyme 1A
Primary source: TAIR:AT4G24940
Locus tag: AT4G24940
See related: Araport:AT4G24940
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AT-SAE1-1; ATSAE1A; F13M23.80; F13M23_80; SUMO-activating enzyme 1A; SUMO-ACTIVATING ENZYME 1A
Summary: Encodes one of the two subunits of the SUMO activation enzyme required during sumolation. Sumolation is a post-translational protein modification process similar to ubiquitination during which a polypeptide (SUMO) is covalently attached to a target protein.
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Genomic context

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See SAE1A in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 10

Sequence:: Chromosome: 4; NC_003075.7 (12823496..12826209)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ha2335 (e-PCR)
- UniSTS:515528

Homology

Orthologs from OrthoDB

NM_118626.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables SUMO activating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables SUMO activating enzyme activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein sumoylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein sumoylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: SUMO-activating enzyme 1A

NP_567712.1

SUMO-activating enzyme 1A (SAE1A); CONTAINS InterPro DOMAIN/s: UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: SUMO-activating enzyme 1B (TAIR:AT5G50580.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

12823496..12826209

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118626.3 → NP_567712.1 SUMO-activating enzyme 1A [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567712.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8VY78, Q9SW32

UniProtKB/TrEMBL

A0A178UWC4, A0A5S9XVK9

Conserved Domains (1) summary

cd01492
Location:11 → 314

Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...